FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2020631966> ?p ?o ?g. }

• W2020631966 endingPage "947" @default.
• W2020631966 startingPage "939" @default.
• W2020631966 abstract "Neutrophils are considered crucial effector cells in the pathophysiology of organ ischemia/reperfusion injury (IRI). Although neutrophil elastase (NE) accounts for a substantial portion of the neutrophil activity, the function of NE in liver IRI remains unclear. This study focuses on the role of NE in the mechanism of liver IRI. Partial warm ischemia was produced in the left and middle hepatic lobes of C57BL/6 mice for 90 minutes, and this was followed by 6 to 24 hours of reperfusion. Mice were treated with neutrophil elastase inhibitor (NEI; 2 mg/kg per os) at 60 minutes prior to the ischemia insult. NEI treatment significantly reduced serum alanine aminotransferase levels in comparison with controls. Histological examination of liver sections revealed that unlike in controls, NEI treatment ameliorated hepatocellular damage and decreased local neutrophil infiltration, as assessed by myeloperoxidase assay, naphthol AS-D chloroacetate esterase stains, and immunohistochemistry (anti-Ly-6G). The expression of pro-inflammatory cytokines (tumor necrosis factor alpha and interleukin 6) and chemokines [chemokine (C-X-C motif) ligand 1 (CXCL-1), CXCL-2, and CXCL-10] was significantly reduced in the NEI treatment group, along with diminished apoptosis, according to terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling staining and caspase-3 activity. In addition, toll-like receptor 4 (TLR4) expression was diminished in NEI-pretreated livers, and this implies a putative role of NE in the TLR4 signal transduction pathway. Thus, targeting NE represents a useful approach for preventing liver IRI and hence expanding the organ donor pool and improving the overall success of liver transplantation. Liver Transpl 15:939-947, 2009. (c) 2009 AASLD." @default.
• W2020631966 created "2016-06-24" @default.
• W2020631966 creator A5016218484 @default.
• W2020631966 creator A5027509326 @default.
• W2020631966 creator A5057053381 @default.
• W2020631966 creator A5057131061 @default.
• W2020631966 creator A5075909338 @default.
• W2020631966 date "2009-07-29" @default.
• W2020631966 modified "2023-10-18" @default.
• W2020631966 title "The inhibition of neutrophil elastase ameliorates mouse liver damage due to ischemia and reperfusion" @default.
• W2020631966 cites W1570767037 @default.
• W2020631966 cites W1571151195 @default.
• W2020631966 cites W1583126278 @default.
• W2020631966 cites W1602835962 @default.
• W2020631966 cites W1899364733 @default.
• W2020631966 cites W1953009759 @default.
• W2020631966 cites W1970665368 @default.
• W2020631966 cites W1975658673 @default.
• W2020631966 cites W1977676109 @default.
• W2020631966 cites W1983590721 @default.
• W2020631966 cites W1984571968 @default.
• W2020631966 cites W1986020721 @default.
• W2020631966 cites W1991611759 @default.
• W2020631966 cites W1998898690 @default.
• W2020631966 cites W2009599333 @default.
• W2020631966 cites W2014745588 @default.
• W2020631966 cites W2025650191 @default.
• W2020631966 cites W2029631026 @default.
• W2020631966 cites W2044237516 @default.
• W2020631966 cites W2049515086 @default.
• W2020631966 cites W2050971607 @default.
• W2020631966 cites W2051104901 @default.
• W2020631966 cites W2051856142 @default.
• W2020631966 cites W2055656686 @default.
• W2020631966 cites W2057809738 @default.
• W2020631966 cites W2064031255 @default.
• W2020631966 cites W2074966179 @default.
• W2020631966 cites W2077262776 @default.
• W2020631966 cites W2077669888 @default.
• W2020631966 cites W2086237673 @default.
• W2020631966 cites W2090165963 @default.
• W2020631966 cites W2091374096 @default.
• W2020631966 cites W2096337838 @default.
• W2020631966 cites W2105754873 @default.
• W2020631966 cites W2108708510 @default.
• W2020631966 cites W2113552021 @default.
• W2020631966 cites W2129794631 @default.
• W2020631966 cites W2135921495 @default.
• W2020631966 cites W2145472566 @default.
• W2020631966 cites W2147041331 @default.
• W2020631966 cites W2150548162 @default.
• W2020631966 cites W2165158922 @default.
• W2020631966 cites W2167021247 @default.
• W2020631966 cites W2167097725 @default.
• W2020631966 cites W2176220887 @default.
• W2020631966 cites W2284379072 @default.
• W2020631966 doi "https://doi.org/10.1002/lt.21770" @default.
• W2020631966 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2752954" @default.
• W2020631966 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19642132" @default.
• W2020631966 hasPublicationYear "2009" @default.
• W2020631966 type Work @default.
• W2020631966 sameAs 2020631966 @default.
• W2020631966 citedByCount "51" @default.
• W2020631966 countsByYear W20206319662012 @default.
• W2020631966 countsByYear W20206319662013 @default.
• W2020631966 countsByYear W20206319662014 @default.
• W2020631966 countsByYear W20206319662015 @default.
• W2020631966 countsByYear W20206319662016 @default.
• W2020631966 countsByYear W20206319662017 @default.
• W2020631966 countsByYear W20206319662018 @default.
• W2020631966 countsByYear W20206319662019 @default.
• W2020631966 countsByYear W20206319662020 @default.
• W2020631966 countsByYear W20206319662021 @default.
• W2020631966 countsByYear W20206319662022 @default.
• W2020631966 countsByYear W20206319662023 @default.
• W2020631966 crossrefType "journal-article" @default.
• W2020631966 hasAuthorship W2020631966A5016218484 @default.
• W2020631966 hasAuthorship W2020631966A5027509326 @default.
• W2020631966 hasAuthorship W2020631966A5057053381 @default.
• W2020631966 hasAuthorship W2020631966A5057131061 @default.
• W2020631966 hasAuthorship W2020631966A5075909338 @default.
• W2020631966 hasBestOaLocation W20206319662 @default.
• W2020631966 hasConcept C126322002 @default.
• W2020631966 hasConcept C13373296 @default.
• W2020631966 hasConcept C142724271 @default.
• W2020631966 hasConcept C154113507 @default.
• W2020631966 hasConcept C181199279 @default.
• W2020631966 hasConcept C185592680 @default.
• W2020631966 hasConcept C196795494 @default.
• W2020631966 hasConcept C203014093 @default.
• W2020631966 hasConcept C203565725 @default.
• W2020631966 hasConcept C204232928 @default.
• W2020631966 hasConcept C2776070231 @default.
• W2020631966 hasConcept C2776317360 @default.
• W2020631966 hasConcept C2776914184 @default.
• W2020631966 hasConcept C2780114680 @default.
• W2020631966 hasConcept C2781044401 @default.
• W2020631966 hasConcept C541997718 @default.

• next