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• W2020633166 abstract "Trichinellosis is a cosmopolitan zoonotic disease affecting a wide variety of animals, including man. Non-encapsulated and encapsulated species diverge with respect to their developmental strategies. Little is known at the molecular level about parasite-derived mediators responsible for host muscle cell transformation occurring during trichinellosis. In this context, host–parasite relationships in Trichinella-infected animals could be related to different host-immune and cell mediators, e.g. nitric oxide (NO). Here, we investigate the stimulatory/inhibitory role of L1 antigens from four encapsulated (T. spiralis, T. britovi, T. nelsoni and T. nativa) and one non-encapsulated (T. pseudospiralis) Trichinella species on NO production from rat macrophages in vitro. Our results demonstrate that encapsulated and non-encapsulated Trichinella species differ in their capacity to stimulate the secretion of NO from host macrophages. Biological significance of these differences should be further assessed in the available experimental models." @default.
• W2020633166 created "2016-06-24" @default.
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• W2020633166 date "2007-01-01" @default.
• W2020633166 modified "2023-10-18" @default.
• W2020633166 title "Trichinella: Differing effects of antigens from encapsulated and non-encapsulated species on in vitro nitric oxide production" @default.
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• W2020633166 doi "https://doi.org/10.1016/j.vetpar.2006.07.026" @default.
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