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• W2020636634 abstract "Autoregulation and tubuloglomerular feedback in normotensive and hypertensive rats. Experiments were performed in control rats and rats with renovascular hypertension to test the hypothesis that adjustments of renal vascular resistance to acute changes of blood pressure (BP) are mediated through an intrarenal feedback control system. In control rats, a change in mean BP from 133 ± 2 to 117 ± 1 (SEM) mm Hg was associated with constancy of kidney glomerular filtration rate (GFR), 1.00 ± 0.08 vs. 0.95 ± 0.04 ml/min.g of kidney wt), and constancy of distally measured nephron GFR, 28.0 ± 2.0 vs. 29.1 ± 2.5 nl/min. In contrast, proximally measured nephron GFR fell significantly from 39.4 ± 3.3 to 32.9 ± 3.2nl/min, suggesting that autoregulatory adjustments require maintained distal fluid delivery. In rats with renovascular hypertension, the kidney GFR of the contralateral non-clipped kidney fell from 0.99 ± 0.06 to 0.57 ± 0.05 and 0.34 ± 0.06 ml/min.g when BP was reduced by aortic clamping from 194 ± 2 to 149 ± 2 and 127 ± 2 mm Hg. The proximally determined nephron GFR fell from 57.2 ± 3.1 to 40.0 ± 1.7 and 28.3 ± 1.8 nl/min, while that measured distally decreased from 53.0 ± 3.6 to 40.3 ± 2.4 and 27.4 ± 1.9 nl/min. Tubuloglomerular feedback was markedly attenuated: the early proximal flow rate fell by only 9.6 ± 2.9% when the microperfusion flow rate in the loop of Henle was raised from 0 to 45 nl/min. Juxtaglomerular renin activity was greatly reduced with a mean of 2.9 ± 0.9 ng of angiotensin II/0.1 mlhr.5 glomeruli. After acute removal_of the clip, autoregulation was studied in the previously clipped kidney at a mean BP of 158 ± 6 mm Hg and after pressure reduction to 114 ± 2 mm Hg by aortic clamping. The kidney GFR averaged 1.18 ± 0.30 and 1.06 ± 0.40 ml/min.g, while the distally measured nephron GFR was 32.2 ± 2.0 and 32.4 ± 2.7 nl/min. Nephron GFR, measured at proximal sites, in contrast, fell from 43.1 ± 3.4 to 37.8 ± 3.3, the mean difference of 5.2± 1.2 nl/min being significant at P Autoregulation et retro-controle tubulo-glomerulaire chez les rats normaux et atteints d'hypertension. Ces experiences ont ete realisees chez des rats controles et des rats atteints d'hypertension arterielle reno-vasculaire pour evaluer l'hypothese selon laquelle les ajustements de la resistance vasculaire renale ont pour mediateur un systeme de retro-controle intra-renal. Chez les rats temoins une modification de la pression arterielle moyenne de 133 ± 2 (SEM) mm Hg a 117 ± 1 mm Hg est associee a un debit de filtration glomerulaire du rein (GFR) qui reste constant (1,00 ± 0,08 vs. 0,95 ± 0,04 ml/min·g de poids de rein) et a un debit de filtration glomerulaire par nephron, mesure dans le tube distal, inchange (28,0 ± 2,0 vs. 29,1 ± 2,5 nl/min). Les debits de filtration glomerulaire des nephrons mesures dans le tube proximal diminuent significativement de 39,4 ± 3,3 a 32,9 ± 3,2 ce qui suggere que les ajustements de l'autoregulation exigent le maintien du debit distal. Chez les rats atteints d'hypertension renovasculaire le GFR du rein controlateral, non clampe, baisse de 0,99 ± 0,06 a 0,57 ± 0,05 et 0,34 ± 0,06 (ml/min·g) quand la pression arterielle est reduite par le clamp aortique de 194 ± 2 a 149 ± 2 et 127 ± 2 mm Hg. Le debit de filtration des nephrons determine dans le tube proximal (nl/min) diminue de 57,2 ± 3,1 a 40,0 ± 1,7 et a 28,3 ± 1,8 alors que le debit mesure dans le tube distal diminue de 53,0 ± 3,6 a 40,3 ± 2,4 et a 27,4 ± 1,9. Le retro-controle tubuloglomerulaire est considerablement attenue: le debit proximal diminue seulement de 9,6 ± 2,9% quand le debit de microperfusion de l'anse de Herle est augmente de 0 a 45 nl/min. L'activite renine juxta-glomerulaire est reduite de facon importante avec une moyenne de 2,9 ± 0,9 ng angiotensine-II/0,1 ml heme.5 glomerules. Immediatement apres l'ablation du clamp l'autoregulation a ete etudiee dans le rein anterieurement clampe a une pression arterielle moyenne de 158 ± 6 mm Hg et apres une reduction de la pression a 114 ± 2 mm Hg par clampage aortique. Le debit de filtration glomerulaire moyen est alors en moyenne de 1,18 ± 0,30 et 1,06 ± 0,40 ml/min·g alors que le debit distal par nephron est de 32,2 ± 2,0 et 32,4 ± 2,7 nl/min. Le debit proximal par nephron, au contraire, diminue de43,l ± 3,4 a 37,8 ± 3,3, la difference moyenne de 5,3 ±1,2 nl/min est significative a P" @default.
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• W2020636634 title "Autoregulation and tubuloglomerular feedback in normotensive and hypertensive rats" @default.
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• W2020636634 doi "https://doi.org/10.1038/ki.1977.110" @default.
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