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- W2020641523 abstract "A convenient and highly efficient one-pot N-alkylation of theophylline from alcohols via N 7-tosyltheophylline (TsTh) is described. In this protocol, the treatment of primary and/or secondary alcohols with a mixture of TsTh and 1,8-diazabicyclo[5.4.0]undec-7-ene in refluxing acetonitrile affords the corresponding N 7-alkyltheophylline in good to excellent yields; the reaction was optimized for solvent and base. This methodology is highly efficient for various structurally diverse primary and secondary alcohols. A plausible mechanism for the one-pot N-alkylation of theophylline with alcohols via TsTh has been suggested." @default.
- W2020641523 created "2016-06-24" @default.
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- W2020641523 date "2014-10-16" @default.
- W2020641523 modified "2023-09-23" @default.
- W2020641523 title "ChemInform Abstract: N7-Tosyltheophylline (TsTh): A Highly Efficient Reagent for the One-Pot Synthesis of N7-Alkyltheophyllines from Alcohols." @default.
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- W2020641523 doi "https://doi.org/10.1002/chin.201444174" @default.
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