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- W2020642801 abstract "The circumsporozoite protein of the malaria parasite Plasmodium falciparum contains regions of nonrepetitive sequences which are predicted to be T cell recognition sites. We synthesized peptides corresponding to three of these regions, and tested their ability to stimulate proliferation of peripheral blood lymphocytes from donors living in a malaria-endemic area, or from nonimmune donors. Cells from 15 out of 22 donors (including 4 of 6 nonimmune individuals) were stimulated by one or more of the peptides. T cell clones specific for one of the peptides were obtained and shown to recognize the native protein purified from sporozoites. These data help to identify T cell epitopes which could be incorporated into a malaria vaccine." @default.
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- W2020642801 date "1988-04-01" @default.
- W2020642801 modified "2023-09-24" @default.
- W2020642801 title "Epitopes recognized by human t lymphocytes on malaria circumsporozoite protein" @default.
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- W2020642801 doi "https://doi.org/10.1002/eji.1830180422" @default.
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