FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2020645947> ?p ?o ?g. }

• W2020645947 endingPage "576" @default.
• W2020645947 startingPage "559" @default.
• W2020645947 abstract "Simple epithelial cells are polygonal in shape, polarized in an apical-basal orientation, and organized into closely adherent sheets, characteristics that result from a variety of cellular specializations and adhesive proteins. These characteristics are lost when the epithelia transform during embryogenesis into mesenchymal cells or after neoplasia into invasive carcinoma cells. Of the syndecan family of transmembrane heparan sulfate proteoglycans, simple epithelia produce predominantly syndecan-1, which is found at basolateral surfaces and within adhesive junctions. To elucidate the function of this syndecan-1, normal murine mammary gland epithelia were made deficient in syndecan-1 by transfection with an expression vector containing the syndecan-1 cDNA in the antisense configuration. Several independently derived clones of stable transfectants contained the antisense cDNA in their genome and expressed the antisense transcript. These grew either as epithelial islands of closely adherent polygonal cells, identical to both the parental cells and the vector-only control transfectants, or as individual elongated fusiform cells that invaded and migrated within collagen gels, like mesenchymal cells, but were anchorage-independent for growth. The clones that retained epithelial characteristics were moderately deficient in cell surface syndecan-1 (greater than 48% of control levels) but did not differ from control cells in expression of beta 1-integrins and E-cadherin, or in F-actin organization. However, the clones of fusiform cells were severely deficient in cell surface syndecan-1 (less than 12% of control levels) and showed rearranged beta 1-integrins, markedly reduced E-cadherin expression, and disorganized F-actin filaments, but retained mammary epithelial markers. Therefore, depleting epithelia of cell surface syndecan-1 alters cell morphology and organization, the arrangement and expression of adhesion molecules, and anchorage-dependent growth controls. Thus, cell surface syndecan-1 is required to maintain the normal phenotype of simple epithelia." @default.
• W2020645947 created "2016-06-24" @default.
• W2020645947 creator A5016953433 @default.
• W2020645947 creator A5039937461 @default.
• W2020645947 creator A5051994090 @default.
• W2020645947 creator A5077177876 @default.
• W2020645947 date "1995-05-01" @default.
• W2020645947 modified "2023-10-17" @default.
• W2020645947 title "Loss of cell surface syndecan-1 causes epithelia to transform into anchorage-independent mesenchyme-like cells." @default.
• W2020645947 cites W1014054951 @default.
• W2020645947 cites W1487226888 @default.
• W2020645947 cites W1488817529 @default.
• W2020645947 cites W1502844891 @default.
• W2020645947 cites W1534240923 @default.
• W2020645947 cites W1573490865 @default.
• W2020645947 cites W1578927156 @default.
• W2020645947 cites W1579838330 @default.
• W2020645947 cites W1580856681 @default.
• W2020645947 cites W1590230123 @default.
• W2020645947 cites W1603982316 @default.
• W2020645947 cites W1837845068 @default.
• W2020645947 cites W1893990735 @default.
• W2020645947 cites W1900479970 @default.
• W2020645947 cites W1915609526 @default.
• W2020645947 cites W1925360706 @default.
• W2020645947 cites W1964333640 @default.
• W2020645947 cites W1964595762 @default.
• W2020645947 cites W1969628563 @default.
• W2020645947 cites W1973930300 @default.
• W2020645947 cites W1985748226 @default.
• W2020645947 cites W1992486637 @default.
• W2020645947 cites W1993638899 @default.
• W2020645947 cites W1998500791 @default.
• W2020645947 cites W1998906348 @default.
• W2020645947 cites W2002344264 @default.
• W2020645947 cites W2003753090 @default.
• W2020645947 cites W2004369793 @default.
• W2020645947 cites W2004687677 @default.
• W2020645947 cites W2010195583 @default.
• W2020645947 cites W2010470883 @default.
• W2020645947 cites W2011812152 @default.
• W2020645947 cites W2017884204 @default.
• W2020645947 cites W2018289835 @default.
• W2020645947 cites W2019383341 @default.
• W2020645947 cites W2021413161 @default.
• W2020645947 cites W2021855690 @default.
• W2020645947 cites W2028253988 @default.
• W2020645947 cites W2034044650 @default.
• W2020645947 cites W2044044042 @default.
• W2020645947 cites W2045233723 @default.
• W2020645947 cites W2050720480 @default.
• W2020645947 cites W2051747697 @default.
• W2020645947 cites W2052574932 @default.
• W2020645947 cites W2058622020 @default.
• W2020645947 cites W2059337147 @default.
• W2020645947 cites W2059877578 @default.
• W2020645947 cites W2061385217 @default.
• W2020645947 cites W2064724355 @default.
• W2020645947 cites W2065404901 @default.
• W2020645947 cites W2069200668 @default.
• W2020645947 cites W2071790834 @default.
• W2020645947 cites W2088130063 @default.
• W2020645947 cites W2089559330 @default.
• W2020645947 cites W2094122987 @default.
• W2020645947 cites W2098703981 @default.
• W2020645947 cites W2100837269 @default.
• W2020645947 cites W2108283255 @default.
• W2020645947 cites W2108283430 @default.
• W2020645947 cites W2109902780 @default.
• W2020645947 cites W2111072594 @default.
• W2020645947 cites W2113142255 @default.
• W2020645947 cites W2113266466 @default.
• W2020645947 cites W2122506460 @default.
• W2020645947 cites W2138754781 @default.
• W2020645947 cites W2164592284 @default.
• W2020645947 cites W2182884407 @default.
• W2020645947 cites W2310123878 @default.
• W2020645947 cites W2398630845 @default.
• W2020645947 cites W2411870411 @default.
• W2020645947 cites W2414199999 @default.
• W2020645947 cites W2427274216 @default.
• W2020645947 cites W2465600923 @default.
• W2020645947 doi "https://doi.org/10.1091/mbc.6.5.559" @default.
• W2020645947 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/301215" @default.
• W2020645947 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7545031" @default.
• W2020645947 hasPublicationYear "1995" @default.
• W2020645947 type Work @default.
• W2020645947 sameAs 2020645947 @default.
• W2020645947 citedByCount "206" @default.
• W2020645947 countsByYear W20206459472012 @default.
• W2020645947 countsByYear W20206459472013 @default.
• W2020645947 countsByYear W20206459472014 @default.
• W2020645947 countsByYear W20206459472015 @default.
• W2020645947 countsByYear W20206459472016 @default.
• W2020645947 countsByYear W20206459472017 @default.
• W2020645947 countsByYear W20206459472018 @default.
• W2020645947 countsByYear W20206459472019 @default.
• W2020645947 countsByYear W20206459472020 @default.

• next