FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2020652334> ?p ?o ?g. }

• W2020652334 endingPage "377" @default.
• W2020652334 startingPage "368" @default.
• W2020652334 abstract "Cleavage factor I(m) (CFI(m)) is a highly conserved component of the eukaryotic mRNA 3' processing machinery that functions in sequence-specific poly(A) site recognition through the collaboration of a 25 kDa subunit containing a Nudix domain and a larger subunit of 59, 68, or 72 kDa containing an RNA recognition motif (RRM). Our previous work demonstrated that CFI(m)25 is both necessary and sufficient for sequence-specific binding of the poly(A) site upstream element UGUA. Here, we report the crystal structure of CFI(m)25 complexed with the RRM domain of CFI(m)68 and RNA. The CFI(m)25 dimer is clasped on opposite sides by two CFI(m)68 RRM domains. Each CFI(m)25 subunit binds one UGUA element specifically. Biochemical analysis indicates that the CFI(m)68 RRMs serve to enhance RNA binding and facilitate RNA looping. The intrinsic ability of CFI(m) to direct RNA looping may provide a mechanism for its function in the regulation of alternative poly(A) site selection." @default.
• W2020652334 created "2016-06-24" @default.
• W2020652334 creator A5013564199 @default.
• W2020652334 creator A5055081181 @default.
• W2020652334 creator A5066431435 @default.
• W2020652334 creator A5088798352 @default.
• W2020652334 date "2011-03-01" @default.
• W2020652334 modified "2023-10-18" @default.
• W2020652334 title "Crystal Structure of a Human Cleavage Factor CFIm25/CFIm68/RNA Complex Provides an Insight into Poly(A) Site Recognition and RNA Looping" @default.
• W2020652334 cites W1539247107 @default.
• W2020652334 cites W1539796472 @default.
• W2020652334 cites W1749659233 @default.
• W2020652334 cites W1851718298 @default.
• W2020652334 cites W1864265177 @default.
• W2020652334 cites W1964675259 @default.
• W2020652334 cites W1965659705 @default.
• W2020652334 cites W1969117624 @default.
• W2020652334 cites W1972059985 @default.
• W2020652334 cites W1977908066 @default.
• W2020652334 cites W1981809235 @default.
• W2020652334 cites W1986191025 @default.
• W2020652334 cites W1988611580 @default.
• W2020652334 cites W1990007398 @default.
• W2020652334 cites W1991612185 @default.
• W2020652334 cites W1993926172 @default.
• W2020652334 cites W1994181184 @default.
• W2020652334 cites W1997706129 @default.
• W2020652334 cites W1999805448 @default.
• W2020652334 cites W2009826707 @default.
• W2020652334 cites W2027403969 @default.
• W2020652334 cites W2034890717 @default.
• W2020652334 cites W2038424676 @default.
• W2020652334 cites W2050002679 @default.
• W2020652334 cites W2052494348 @default.
• W2020652334 cites W2063530272 @default.
• W2020652334 cites W2087744052 @default.
• W2020652334 cites W2089029993 @default.
• W2020652334 cites W2093295511 @default.
• W2020652334 cites W2097493124 @default.
• W2020652334 cites W2097572021 @default.
• W2020652334 cites W2102014108 @default.
• W2020652334 cites W2102887078 @default.
• W2020652334 cites W2106774938 @default.
• W2020652334 cites W2109184569 @default.
• W2020652334 cites W2109302137 @default.
• W2020652334 cites W2109618665 @default.
• W2020652334 cites W2111403104 @default.
• W2020652334 cites W2114918874 @default.
• W2020652334 cites W2115612309 @default.
• W2020652334 cites W2122339645 @default.
• W2020652334 cites W2124026197 @default.
• W2020652334 cites W2129429612 @default.
• W2020652334 cites W2133350967 @default.
• W2020652334 cites W2138717326 @default.
• W2020652334 cites W2138998454 @default.
• W2020652334 cites W2139253560 @default.
• W2020652334 cites W2143993503 @default.
• W2020652334 cites W2146521441 @default.
• W2020652334 cites W2152869747 @default.
• W2020652334 cites W2159864549 @default.
• W2020652334 cites W2164118546 @default.
• W2020652334 cites W4302343761 @default.
• W2020652334 doi "https://doi.org/10.1016/j.str.2010.12.021" @default.
• W2020652334 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3056899" @default.
• W2020652334 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21295486" @default.
• W2020652334 hasPublicationYear "2011" @default.
• W2020652334 type Work @default.
• W2020652334 sameAs 2020652334 @default.
• W2020652334 citedByCount "123" @default.
• W2020652334 countsByYear W20206523342012 @default.
• W2020652334 countsByYear W20206523342013 @default.
• W2020652334 countsByYear W20206523342014 @default.
• W2020652334 countsByYear W20206523342015 @default.
• W2020652334 countsByYear W20206523342016 @default.
• W2020652334 countsByYear W20206523342017 @default.
• W2020652334 countsByYear W20206523342018 @default.
• W2020652334 countsByYear W20206523342019 @default.
• W2020652334 countsByYear W20206523342020 @default.
• W2020652334 countsByYear W20206523342021 @default.
• W2020652334 countsByYear W20206523342022 @default.
• W2020652334 countsByYear W20206523342023 @default.
• W2020652334 crossrefType "journal-article" @default.
• W2020652334 hasAuthorship W2020652334A5013564199 @default.
• W2020652334 hasAuthorship W2020652334A5055081181 @default.
• W2020652334 hasAuthorship W2020652334A5066431435 @default.
• W2020652334 hasAuthorship W2020652334A5088798352 @default.
• W2020652334 hasBestOaLocation W20206523341 @default.
• W2020652334 hasConcept C104292427 @default.
• W2020652334 hasConcept C104317684 @default.
• W2020652334 hasConcept C105580179 @default.
• W2020652334 hasConcept C107824862 @default.
• W2020652334 hasConcept C126142528 @default.
• W2020652334 hasConcept C151730666 @default.
• W2020652334 hasConcept C153911025 @default.
• W2020652334 hasConcept C158730165 @default.
• W2020652334 hasConcept C175156509 @default.
• W2020652334 hasConcept C178790620 @default.
• W2020652334 hasConcept C185592680 @default.

• next