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• W2020657007 endingPage "13" @default.
• W2020657007 startingPage "1" @default.
• W2020657007 abstract "Down syndrome (DS) is a condition where a complete or segmental chromosome 21 trisomy causes variable intellectual disability, and progressive memory loss and neurodegeneration with age. Many research groups have examined development of the brain in DS individuals, but studies on age-related changes should also be considered, with the increased lifespan observed in DS. DS leads to pathological hallmarks of Alzheimer's disease (AD) by 40 or 50 years of age. Progressive age-related memory deficits occurring in both AD and in DS have been connected to degeneration of several neuronal populations, but mechanisms are not fully elucidated. Inflammation and oxidative stress are early events in DS pathology, and focusing on these pathways may lead to development of successful intervention strategies for AD associated with DS. Here we discuss recent findings and potential treatment avenues regarding development of AD neuropathology and memory loss in DS." @default.
• W2020657007 created "2016-06-24" @default.
• W2020657007 creator A5023768178 @default.
• W2020657007 creator A5035950340 @default.
• W2020657007 creator A5061368595 @default.
• W2020657007 date "2012-01-01" @default.
• W2020657007 modified "2023-10-03" @default.
• W2020657007 title "Age-Related Neurodegeneration and Memory Loss in Down Syndrome" @default.
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