FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2020658418> ?p ?o ?g. }

• W2020658418 endingPage "08KA03" @default.
• W2020658418 startingPage "08KA03" @default.
• W2020658418 abstract "We have developed methods and systems of analyzing epigenetic information in cells to expand our understanding of how living systems are determined. Because cells are minimum units reflecting epigenetic information, which is considered to map the history of a parallel-processing recurrent network of biochemical reactions, their behaviors cannot be explained by considering only conventional deonucleotide (DNA) information-processing events. The role of epigenetic information on cells, which complements their genetic information, was inferred by comparing predictions from genetic information with cell behaviour observed under conditions chosen to reveal adaptation processes and community effects. A system of analyzing epigenetic information, on-chip cellomics technology, has been developed starting from the twin complementary viewpoints of cell regulation as an “algebraic” system (emphasis on temporal aspects) and as a “geometric” system (emphasis on spatial aspects) exploiting microfabrication technology and a reconstructive approach of cellular systems not only for single cell-based subjects such as Escherichia coli and macrophages but also for cellular networks like the community effect of cardiomyocytes and plasticity in neuronal networks. One of the most important contributions of this study was to be able to reconstruct the concept of a cell regulatory network from the “local” (molecules expressed at certain times and places) to the “global” (the cell as a viable, functioning system). Knowledge of epigenetic information, which we can control and change during cell lives, complements the genetic variety, and these two types of information are indispensable for living organisms. This new knowlege has the potential to be the basis of cell-based biological and medical fields such as those involving cell-based drug screening and the regeneration of organs from stem cells." @default.
• W2020658418 created "2016-06-24" @default.
• W2020658418 creator A5091835034 @default.
• W2020658418 date "2012-08-01" @default.
• W2020658418 modified "2023-09-23" @default.
• W2020658418 title "On-Chip Cellomics: Constructive Understanding of Multicellular Network Using On-Chip Cellomics Technology" @default.
• W2020658418 cites W144703585 @default.
• W2020658418 cites W1481590818 @default.
• W2020658418 cites W1488704456 @default.
• W2020658418 cites W1491978831 @default.
• W2020658418 cites W1522226996 @default.
• W2020658418 cites W1627947508 @default.
• W2020658418 cites W1645305843 @default.
• W2020658418 cites W1667521611 @default.
• W2020658418 cites W1855561741 @default.
• W2020658418 cites W1884828300 @default.
• W2020658418 cites W1946177469 @default.
• W2020658418 cites W1948887717 @default.
• W2020658418 cites W1964681955 @default.
• W2020658418 cites W1965931428 @default.
• W2020658418 cites W1972081276 @default.
• W2020658418 cites W1976612447 @default.
• W2020658418 cites W1978173381 @default.
• W2020658418 cites W1978319180 @default.
• W2020658418 cites W1979581724 @default.
• W2020658418 cites W1986127144 @default.
• W2020658418 cites W1988188173 @default.
• W2020658418 cites W1988791304 @default.
• W2020658418 cites W1990111162 @default.
• W2020658418 cites W1993255119 @default.
• W2020658418 cites W1994106464 @default.
• W2020658418 cites W1994265235 @default.
• W2020658418 cites W1995636525 @default.
• W2020658418 cites W1999777663 @default.
• W2020658418 cites W2001631200 @default.
• W2020658418 cites W2002140494 @default.
• W2020658418 cites W2007500238 @default.
• W2020658418 cites W2007580663 @default.
• W2020658418 cites W2008667804 @default.
• W2020658418 cites W2015960003 @default.
• W2020658418 cites W2017457274 @default.
• W2020658418 cites W2017997231 @default.
• W2020658418 cites W2018435536 @default.
• W2020658418 cites W2031314781 @default.
• W2020658418 cites W2032188063 @default.
• W2020658418 cites W2032570745 @default.
• W2020658418 cites W2033314535 @default.
• W2020658418 cites W2036984726 @default.
• W2020658418 cites W2037512980 @default.
• W2020658418 cites W2045387730 @default.
• W2020658418 cites W2046356120 @default.
• W2020658418 cites W2051002031 @default.
• W2020658418 cites W2054395943 @default.
• W2020658418 cites W2055384987 @default.
• W2020658418 cites W2056046435 @default.
• W2020658418 cites W2057210002 @default.
• W2020658418 cites W2061198942 @default.
• W2020658418 cites W2061549863 @default.
• W2020658418 cites W2063535898 @default.
• W2020658418 cites W2067072785 @default.
• W2020658418 cites W2068437492 @default.
• W2020658418 cites W2069310511 @default.
• W2020658418 cites W2069674769 @default.
• W2020658418 cites W2071262627 @default.
• W2020658418 cites W2071902635 @default.
• W2020658418 cites W2072239613 @default.
• W2020658418 cites W2077046573 @default.
• W2020658418 cites W2079870118 @default.
• W2020658418 cites W2086037466 @default.
• W2020658418 cites W2088273806 @default.
• W2020658418 cites W2100809095 @default.
• W2020658418 cites W2103540918 @default.
• W2020658418 cites W2108461844 @default.
• W2020658418 cites W2110014101 @default.
• W2020658418 cites W2111167674 @default.
• W2020658418 cites W2111643738 @default.
• W2020658418 cites W2113372755 @default.
• W2020658418 cites W2116760959 @default.
• W2020658418 cites W2125082136 @default.
• W2020658418 cites W2125987139 @default.
• W2020658418 cites W2131135346 @default.
• W2020658418 cites W2134635077 @default.
• W2020658418 cites W2134759932 @default.
• W2020658418 cites W2138090184 @default.
• W2020658418 cites W2138977668 @default.
• W2020658418 cites W2139891988 @default.
• W2020658418 cites W2142046859 @default.
• W2020658418 cites W2145492799 @default.
• W2020658418 cites W2146613933 @default.
• W2020658418 cites W2149134207 @default.
• W2020658418 cites W2152483372 @default.
• W2020658418 cites W2156383937 @default.
• W2020658418 cites W2163822035 @default.
• W2020658418 cites W2169849402 @default.
• W2020658418 cites W2170400061 @default.
• W2020658418 cites W2171280873 @default.
• W2020658418 cites W2171868298 @default.
• W2020658418 doi "https://doi.org/10.1143/jjap.51.08ka03" @default.

• next