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• W2020658872 abstract "Microbial resistance to the available drugs poses a serious threat in modern medicine. We report the design, synthesis and in vitro antimicrobial evaluation of new functionalized 2,3-dihydrothiazoles and 4-thiazolidinones tagged with sulfisoxazole moiety. Compound 8d was most active against Bacillis subtilis (MIC, 0.007 µg/mL). Moreover, compounds 7c–d and 8c displayed significant activities against B. subtilis and Streptococcus pneumoniae (MIC, 0.03–0.06 µg/mL and 0.06–0.12 µg/mL versus ampicillin 0.24 µg/mL and 0.12 µg/mL; respectively). Compounds 7a and 7c–d were highly potent against Escherichia coli (MIC, 0.49–0.98 µg/mL versus gentamycin 1.95 µg/mL). On the other hand, compounds 7e and 9c were fourfolds more active than amphotericin B against Syncephalastrum racemosum. Molecular docking studies showed that the synthesized compounds could act as inhibitors for the dihydropteroate synthase enzyme (DHPS). This study is a platform for the future design of more potent antimicrobial agents." @default.
• W2020658872 created "2016-06-24" @default.
• W2020658872 creator A5028771423 @default.
• W2020658872 creator A5052805675 @default.
• W2020658872 creator A5063279652 @default.
• W2020658872 date "2015-03-27" @default.
• W2020658872 modified "2023-10-04" @default.
• W2020658872 title "Design, synthesis, antimicrobial evaluation and molecular docking studies of some new 2,3-dihydrothiazoles and 4-thiazolidinones containing sulfisoxazole" @default.
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• W2020658872 doi "https://doi.org/10.3109/14756366.2015.1016514" @default.
• W2020658872 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25815670" @default.
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