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• W2020660611 endingPage "598" @default.
• W2020660611 startingPage "588" @default.
• W2020660611 abstract "Abstract Although the existence of a massive projection from the caudal intralaminar nuclei of the thalamus [i.e. the centromedian (CM) and parafascicular nuclei] to the striatum is well documented, the effects of CM activation upon striatal cells remain poorly understood. Therefore, we studied the effects of electrical stimulation of CM on the electrophysiological activity of striatal neurons, and on striatal levels of γ‐aminobutyric acid (GABA) and acetylcholine in rhesus monkeys. Striatal cells did not respond to single‐pulse stimulation (bipolar biphasic stimulation, 175–500 μA), but the large majority of recorded neurons responded to burst stimulation (100 Hz, 1 s, 150–175 μA) of CM, often with a delay of tens of milliseconds. Striatal phasically active neurons, which likely correspond to projection neurons, responded mainly with increases in firing (13/28 cells), while tonically active neurons (likely cholinergic interneurons) often showed combinations of increases and decreases in firing (24/46 cells). In microdialysis studies, CM stimulation led to a reduction of striatal acetylcholine levels. This effect was prevented by addition of the GABA‐A receptor antagonist gabazine to the microdialysis fluid. We conclude that CM stimulation frequently results in striatal response patterns with excitatory and inhibitory components. Under the conditions chosen here, the specific patterns of striatal responses to CM stimulation are likely the result of striatal processing of thalamic inputs. Through these indirect effects, local CM stimulation may engage large portions of the striatum. These effects may be relevant in the interpretation of the therapeutic effects of CM stimulation for the treatment of neurological disorders." @default.
• W2020660611 created "2016-06-24" @default.
• W2020660611 creator A5042569468 @default.
• W2020660611 creator A5048541432 @default.
• W2020660611 creator A5051289855 @default.
• W2020660611 creator A5056482545 @default.
• W2020660611 date "2009-02-01" @default.
• W2020660611 modified "2023-10-12" @default.
• W2020660611 title "Effects of stimulation of the centromedian nucleus of the thalamus on the activity of striatal cells in awake rhesus monkeys" @default.
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• W2020660611 doi "https://doi.org/10.1111/j.1460-9568.2008.06598.x" @default.
• W2020660611 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4430668" @default.
• W2020660611 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19175404" @default.
• W2020660611 hasPublicationYear "2009" @default.
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