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- W2020661282 abstract "Recurrent miscarriage is a heterogeneous condition. While the role of acquired thrombophilia has been accepted as an etiology of recurrent miscarriage, the contribution of specific inherited thrombophilic genes to this disorder has remained controversial. We compared the prevalence of 10 thrombophilic gene mutations in 75 patients with a history of recurrent miscarriages with 14 fertile control women. Prospective observational study. Seventy-five (75) women with a history of 2 or more consecutive abortions and 14 women with at least 1 live birth and no miscarriages had buccal swabs taken and analyzed for the following 10 gene mutations using polymerase chain reaction techniques: Factor V G1691A, Factor V H1299R (R2), Factor V Y1702C, Factor II Prothrombin G20210A, Factor XIII V34L, β-Fibrinogen -453G>A, PAI-1. 4G/5G, HPA1 a/b(L33P), MTHFR C677T, MTHFR A1298C. No differences in the frequency of specific gene mutations were detected when women with recurrent miscarriages were compared with control women. However, the prevalence of total gene mutations among patients with a recurrent miscarriage was significantly higher than among controls. More than 3 gene mutations among the 10 genes studies were observed in 68% of women with recurrent miscarriage and 21% of controls (Relative risk = 0.4073, 95% conficence interval 0.2653–0.6253, P=0.0019). Inherited thrombophilias are associated with recurrent miscarriage. This association is manifest by total number of mutations rather than specific genes involved." @default.
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- W2020661282 date "2004-09-01" @default.
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- W2020661282 title "Multiple thrombophilic gene mutations rather than specific gene mutations are risk factors for recurrent miscarriage" @default.
- W2020661282 doi "https://doi.org/10.1016/j.fertnstert.2004.07.154" @default.
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