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- W2020662056 abstract "Macromolecular binding of metals is thought to be a prerequisite for induction of metal sensitivity. In this study, the binding of cobalt(II) to blood componenets was investigated. Incubation of 60Co with blood yielded a mean erythrocyte binding of 10.3 × 107 Co atoms/cell. Incubation of the metal with serum resulted in binding of 8.3 × 10−9 mol Co/mg protein. A comparison was made with analogous binding of chromium(III), a metal recognized for its sensitizing potency. Binding of chromium to proteins and blood cells was 20-fold higher than that obtained with cobalt. With both metals, binding to serum proteins was non-specific. The greater binding by chromium, when compared with cobalt, is consistent with the greater sensitizing ability of this metal." @default.
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- W2020662056 date "1984-03-01" @default.
- W2020662056 modified "2023-09-24" @default.
- W2020662056 title "Comparison of cobalt and chromium binding to blood elements" @default.
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- W2020662056 doi "https://doi.org/10.1016/0300-483x(84)90123-9" @default.
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