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• W2020664562 abstract "CD4(+) T-cell help enables antiviral CD8(+) T cells to differentiate into fully competent memory cells and sustains CD8(+) T-cell-mediated immunity during persistent virus infection. We recently reported that mice of C57BL/6 and C3H strains differ in their dependence on CD28 and CD40L costimulation for long-term control of infection by polyoma virus, a persistent mouse pathogen. In this study, we asked whether mice of these inbred strains also vary in their requirement for CD4(+) T-cell help for generating and maintaining polyoma virus-specific CD8(+) T cells. CD4(+) T-cell-depleted C57BL/6 mice mounted a robust antiviral CD8(+) T-cell response during acute infection, whereas unhelped CD8(+) T-cell effectors in C3H mice were functionally impaired during acute infection and failed to expand upon antigenic challenge during persistent infection. Using (C57BL/6 x C3H)F(1) mice, we found that the dispensability for CD4(+) T-cell help for the H-2(b)-restricted polyoma virus-specific CD8(+) T-cell response during acute infection extends to the H-2(k)-restricted antiviral CD8(+) T cells. Our findings demonstrate that dependence on CD4(+) T-cell help for antiviral CD8(+) T-cell effector differentiation can vary among allogeneic strains of inbred mice." @default.
• W2020664562 created "2016-06-24" @default.
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• W2020664562 date "2007-12-15" @default.
• W2020664562 modified "2023-10-03" @default.
• W2020664562 title "Allogeneic Differences in the Dependence on CD4⁺T-Cell Help for Virus-Specific CD8⁺T-Cell Differentiation" @default.
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• W2020664562 doi "https://doi.org/10.1128/jvi.01778-07" @default.
• W2020664562 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2168883" @default.
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