FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2020665514> ?p ?o ?g. }

• W2020665514 endingPage "1134" @default.
• W2020665514 startingPage "1123" @default.
• W2020665514 abstract "Little is known about the impact of type 2 diabetes mellitus (DM) on coronary arteriole remodeling. The aim of this study was to determine the mechanisms that underlie coronary arteriole structural remodeling in type 2 diabetic (db/db) mice. Passive structural properties of septal coronary arterioles isolated from 12- to 16-week-old diabetic db/db and control mice were assessed by pressure myography. Coronary arterioles from 12-week-old db/db mice were structurally similar to age-matched controls. By 16 weeks of age, coronary wall thickness was increased in db/db arterioles (p < 0.01), while luminal diameter was reduced (control: 118 ± 5 μm; db/db: 102 ± 4 μm, p < 0.05), augmenting the wall-to-lumen ratio by 58% (control: 5.9 ± 0.6; db/db: 9.5 ± 0.4, p < 0.001). Inward hypertrophic remodeling was accompanied by a 56% decrease in incremental elastic modulus (p < 0.05, indicating decreased vessel coronary wall stiffness) and a ~30% reduction in coronary flow reserve (CFR) in diabetic mice. Interestingly, aortic pulse wave velocity and femoral artery incremental elastic modulus were increased (p < 0.05) in db/db mice, indicating macrovascular stiffness. Molecular tissue analysis revealed increased elastin-to-collagen ratio in diabetic coronaries when compared to control and a decrease in the same ratio in the diabetic aortas. These data show that coronary arterioles isolated from type 2 diabetic mice undergo inward hypertrophic remodeling associated with decreased stiffness and increased elastin-to-collagen ratio which results in a decreased CFR. This study suggests that coronary microvessels undergo a different pattern of remodeling from macrovessels in type 2 DM." @default.
• W2020665514 created "2016-06-24" @default.
• W2020665514 creator A5000642941 @default.
• W2020665514 creator A5001824142 @default.
• W2020665514 creator A5002637102 @default.
• W2020665514 creator A5006396363 @default.
• W2020665514 creator A5018145014 @default.
• W2020665514 creator A5036424676 @default.
• W2020665514 creator A5040205488 @default.
• W2020665514 creator A5049929544 @default.
• W2020665514 creator A5051855937 @default.
• W2020665514 creator A5076776076 @default.
• W2020665514 date "2011-07-10" @default.
• W2020665514 modified "2023-09-24" @default.
• W2020665514 title "Coronary arterioles in type 2 diabetic (db/db) mice undergo a distinct pattern of remodeling associated with decreased vessel stiffness" @default.
• W2020665514 cites W1963641274 @default.
• W2020665514 cites W1964030946 @default.
• W2020665514 cites W1966264818 @default.
• W2020665514 cites W1968849802 @default.
• W2020665514 cites W1971284328 @default.
• W2020665514 cites W1991514810 @default.
• W2020665514 cites W2003020475 @default.
• W2020665514 cites W2008831099 @default.
• W2020665514 cites W2008965338 @default.
• W2020665514 cites W2020053653 @default.
• W2020665514 cites W2022164830 @default.
• W2020665514 cites W2025309753 @default.
• W2020665514 cites W2028212562 @default.
• W2020665514 cites W2035620169 @default.
• W2020665514 cites W2039949144 @default.
• W2020665514 cites W2041760084 @default.
• W2020665514 cites W2043060401 @default.
• W2020665514 cites W2051192888 @default.
• W2020665514 cites W2057770226 @default.
• W2020665514 cites W2059143419 @default.
• W2020665514 cites W2064558231 @default.
• W2020665514 cites W2067757134 @default.
• W2020665514 cites W2067937737 @default.
• W2020665514 cites W2069443069 @default.
• W2020665514 cites W2077549180 @default.
• W2020665514 cites W2080678317 @default.
• W2020665514 cites W2082629387 @default.
• W2020665514 cites W2089853846 @default.
• W2020665514 cites W2094550322 @default.
• W2020665514 cites W2101104783 @default.
• W2020665514 cites W2104824409 @default.
• W2020665514 cites W2104842795 @default.
• W2020665514 cites W2105061132 @default.
• W2020665514 cites W2106776390 @default.
• W2020665514 cites W2107516773 @default.
• W2020665514 cites W2111247788 @default.
• W2020665514 cites W2112936297 @default.
• W2020665514 cites W2112980028 @default.
• W2020665514 cites W2114570899 @default.
• W2020665514 cites W2130883549 @default.
• W2020665514 cites W2134256354 @default.
• W2020665514 cites W2134287276 @default.
• W2020665514 cites W2143334710 @default.
• W2020665514 cites W2144705976 @default.
• W2020665514 cites W2145121523 @default.
• W2020665514 cites W2147355064 @default.
• W2020665514 cites W2161474086 @default.
• W2020665514 cites W2163941933 @default.
• W2020665514 cites W2168547726 @default.
• W2020665514 cites W2169381634 @default.
• W2020665514 cites W2171696642 @default.
• W2020665514 cites W2975364463 @default.
• W2020665514 cites W4249997197 @default.
• W2020665514 doi "https://doi.org/10.1007/s00395-011-0201-0" @default.
• W2020665514 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3229644" @default.
• W2020665514 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21744279" @default.
• W2020665514 hasPublicationYear "2011" @default.
• W2020665514 type Work @default.
• W2020665514 sameAs 2020665514 @default.
• W2020665514 citedByCount "59" @default.
• W2020665514 countsByYear W20206655142012 @default.
• W2020665514 countsByYear W20206655142013 @default.
• W2020665514 countsByYear W20206655142014 @default.
• W2020665514 countsByYear W20206655142015 @default.
• W2020665514 countsByYear W20206655142016 @default.
• W2020665514 countsByYear W20206655142017 @default.
• W2020665514 countsByYear W20206655142018 @default.
• W2020665514 countsByYear W20206655142020 @default.
• W2020665514 countsByYear W20206655142021 @default.
• W2020665514 countsByYear W20206655142022 @default.
• W2020665514 countsByYear W20206655142023 @default.
• W2020665514 crossrefType "journal-article" @default.
• W2020665514 hasAuthorship W2020665514A5000642941 @default.
• W2020665514 hasAuthorship W2020665514A5001824142 @default.
• W2020665514 hasAuthorship W2020665514A5002637102 @default.
• W2020665514 hasAuthorship W2020665514A5006396363 @default.
• W2020665514 hasAuthorship W2020665514A5018145014 @default.
• W2020665514 hasAuthorship W2020665514A5036424676 @default.
• W2020665514 hasAuthorship W2020665514A5040205488 @default.
• W2020665514 hasAuthorship W2020665514A5049929544 @default.
• W2020665514 hasAuthorship W2020665514A5051855937 @default.
• W2020665514 hasAuthorship W2020665514A5076776076 @default.
• W2020665514 hasBestOaLocation W20206655142 @default.

• next