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- W2020667461 abstract "The Ca 2+ ion binding of factor VIIa and the derivative lacking the γ‐carboxyglutamic acid domain, des(1–38) factor VIIa, was investigated using intrinsic protein fluorescence and Tb 3+ ion phosphorescence methods. Binding of Ca 2+ ions giving rise to a decrease in the intrinsic protein fluorescence (approximately 50% at saturating conditions) is seen with both proteins. Each of the saturation curves is in accordance with the formation of a 1:1 complex of factor VIIa‐Ca 2+ ( K D ∼30 μM) and des(1–38) factor VIIa‐Ca 2+ ( K D ∼40 μM)). Yet another Ca 2+ ion binding site reveals itself in each protein in Tb 3+ ion phosphorescence experiments. Ca 2+ ion competition studies have showed 1:1 complexes ( K D ′s∼2 mM). The results are interpreted in terms of two different Ca 2+ ion binding sites, one in the EGF‐1 domain and one in the Gly‐209‐Gin‐221 loop of the serine proteinase part." @default.
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- W2020667461 date "1992-07-20" @default.
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- W2020667461 title "Two different Ca<sup>2+</sup>ion binding sites in factor VIIa and in des(1-38) factor VIIa" @default.
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- W2020667461 doi "https://doi.org/10.1016/0014-5793(92)81014-d" @default.
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