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• W2020667562 abstract "Aim: Several HLA alleles have been associated with antiepileptic drugs (AEDs)-induced cutaneous adverse drug reactions (cADRs) in different populations; however, this has not been investigated in Mexican Mestizos (MM). Thus, the purpose of this preliminary study was to determine the association of HLA class I alleles with AED-induced cADRs in MM patients. Materials & methods: This case–control association study included 21 MM patients with phenytoin (PHT)-, carbamazepine (CBZ)-, or lamotrigine (LTG)-induced maculopapular exanthema (MPE) or Stevens–Johnson syndrome (SJS); 31 MM patients tolerant to the same AEDs; and 225 unrelated, healthy MM volunteers. HLA class I genotyping was performed. Differences in HLA allele frequencies between AED-induced cADR patients and AED-tolerant patients were assessed. Frequencies of alleles possibly associated with AED-induced cADRs in MM patients were compared with those in MM population. Results: The frequency of HLA-C*08:01 allele in PHT-induced MPE was higher than that in the PHT-tolerant group (p c = 0.0179) or in the MM population (p c < 0.0001). For the first time, HLA-A*02:01:01/-B*35:01:01/-C*04:01:01 haplotype was associated with LTG-induced MPE (p c = 0.0048 for LTG-tolerant groups and p c < 0.0001 for MM population). Conclusion: Our data suggest the HLA-A*02:01:01/-B*35:01:01/-C*04:01:01 haplotype may be a biomarker for LTG-induced MPE and the HLA-C*08:01 allele for PHT-induced MPE. We also identified HLA-A*01:01:01 and -A*31:01:02 as candidates alleles associated with CBZ-induced MPE in MM patients. However, further investigations are necessary to confirm these findings. Original submitted 28 March 2014; Revision submitted 15 September 2014" @default.
• W2020667562 created "2016-06-24" @default.
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• W2020667562 date "2014-11-01" @default.
• W2020667562 modified "2023-10-18" @default.
• W2020667562 title "<i>HLA</i>-<i>A*02:01:01</i>/<i>-B*35:01:01</i>/<i>-C*04:01:01</i> haplotype associated with lamotrigine-induced maculopapular exanthema in Mexican Mestizo patients" @default.
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• W2020667562 doi "https://doi.org/10.2217/pgs.14.135" @default.
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