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- W2020670811 abstract "The isofloxythepin ( I ) metabolite IV was synthesized via the acids IX and XI and the esters X and XII . The enamine VIII was prepared from 3-fluoro-8-(2-propyl)dibenzo[ b,f ]thiepin-10(11 H )-one by two methods and was reduced to I . Cloflumide ( II ) was obtained by reaction of 2,10-dichloro-7-fluoro-10,11-dihydrodibenzo[ b,f ]thiepin with 3-(1-piperazinyl)propionamide and was oxidized to the sulfoxide XVI . The unsaturated analogue XVII of clopithepin ( III ) was prepared from 2-chlorodibenzo[ b,f ]thiepin-10(11 H )-one by reaction with 2-bromoethanol in the presence of 4-toluenesulfonic acid in boiling benzene and by the following substitution reaction with 2-(1-piperazinyl)ethanol. An improved synthesis of 6-methyldibenzo[ b,f ]thiepin-10(11 H )-one ( XIX ) was elaborated. The acid XXVII was synthesized and cyclized with polyphosphate ester. A mixture of compounds was formed from which the ketone XXXVI was isolated and processed by reaction with formamide and formic acid at 200 °C. One of the products was characterized as the formamide XXXIII and was reduced with lithium aluminium hydride to a basic product supposed to be XXXIV . A series of by-products was isolated and characterized. The enamine VIII (V⁄FB-17 156) was found to be a strong neuroleptic agent, similar to isofloxythepin ( I ). The enol ether XVII (V⁄FB-17 733) was characterized as a mild, practically noncataleptic neuroleptic agent." @default.
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- W2020670811 date "1990-01-01" @default.
- W2020670811 modified "2023-09-23" @default.
- W2020670811 title "Tricyclic neuroleptics: Synthesis of metabolites of isofloxythepin and some related compounds" @default.
- W2020670811 doi "https://doi.org/10.1135/cccc19902282" @default.
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