FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2020671115> ?p ?o ?g. }

• W2020671115 endingPage "1286" @default.
• W2020671115 startingPage "1275" @default.
• W2020671115 abstract "Dendritic cells (DC) dictate not only the type of T-cell immunity, but also homing patterns of T cells in mice. In humans, we characterized normal human gut DC and tested whether gut-specific homeostatic DC could be generated from blood precursors by factors in the gut microenvironment.We characterized the phenotype and function of healthy human gut DC compared with blood and skin DC, and studied whether conditioning of blood DC in the presence of colonic biopsy supernatants (Bx-SN) induced gut-like phenotype and functions.Blood DC mostly expressed both gut and skin homing markers, indicating potential to migrate to both major immune surface organs, and induced multi-homing T cells. However, DC within gut or skin did not demonstrate this multi-homing phenotype, were tissue-specific, and induced tissue-specific T cells. Human gut DC were less stimulatory for allogeneic T cells than their dermal and blood counterparts. Human blood DC cultured in vitro lost homing marker expression. Conditioning of human enriched blood DC with colonic Bx-SN from healthy controls induced a gut-homing phenotype and a homeostatic profile. Moreover, Bx-SN-conditioned DC demonstrated a restricted T-cell stimulatory capacity and preferentially induced gut-specific T cells. Retinoic acid and transforming growth factor beta (TGF-β) mediated the acquisition of the gut-homing and homeostatic properties, respectively, induced by colonic Bx-SN on blood enriched DC.Tissue-specific factors manipulate immunity via modulating characteristics of DC and may provide tools to generate tissue-specific immunotherapy." @default.
• W2020671115 created "2016-06-24" @default.
• W2020671115 creator A5003478464 @default.
• W2020671115 creator A5005523458 @default.
• W2020671115 creator A5011038778 @default.
• W2020671115 creator A5040981628 @default.
• W2020671115 creator A5048213341 @default.
• W2020671115 creator A5054069732 @default.
• W2020671115 creator A5061019212 @default.
• W2020671115 creator A5064125430 @default.
• W2020671115 creator A5073349527 @default.
• W2020671115 creator A5075268369 @default.
• W2020671115 creator A5086629019 @default.
• W2020671115 date "2012-07-01" @default.
• W2020671115 modified "2023-10-14" @default.
• W2020671115 title "Human Gut-Specific Homeostatic Dendritic Cells Are Generated from Blood Precursors by the Gut Microenvironment" @default.
• W2020671115 cites W1535141082 @default.
• W2020671115 cites W1537188001 @default.
• W2020671115 cites W1973312218 @default.
• W2020671115 cites W1973834362 @default.
• W2020671115 cites W1976379219 @default.
• W2020671115 cites W1978023299 @default.
• W2020671115 cites W1982139831 @default.
• W2020671115 cites W1984127959 @default.
• W2020671115 cites W1986070087 @default.
• W2020671115 cites W1987889570 @default.
• W2020671115 cites W1988712793 @default.
• W2020671115 cites W1991804457 @default.
• W2020671115 cites W2006060684 @default.
• W2020671115 cites W2010011171 @default.
• W2020671115 cites W2018938924 @default.
• W2020671115 cites W2024263435 @default.
• W2020671115 cites W2025431064 @default.
• W2020671115 cites W2031551895 @default.
• W2020671115 cites W2032793030 @default.
• W2020671115 cites W2035213168 @default.
• W2020671115 cites W2041483393 @default.
• W2020671115 cites W2050417626 @default.
• W2020671115 cites W2053891457 @default.
• W2020671115 cites W2062363040 @default.
• W2020671115 cites W2080645266 @default.
• W2020671115 cites W2081097093 @default.
• W2020671115 cites W2081522241 @default.
• W2020671115 cites W2085233986 @default.
• W2020671115 cites W2085875957 @default.
• W2020671115 cites W2086226733 @default.
• W2020671115 cites W2094979669 @default.
• W2020671115 cites W2103384599 @default.
• W2020671115 cites W2115024315 @default.
• W2020671115 cites W2115138114 @default.
• W2020671115 cites W2123307454 @default.
• W2020671115 cites W2126000068 @default.
• W2020671115 cites W2127035465 @default.
• W2020671115 cites W2128444087 @default.
• W2020671115 cites W2128509983 @default.
• W2020671115 cites W2128712834 @default.
• W2020671115 cites W2132411790 @default.
• W2020671115 cites W2145164692 @default.
• W2020671115 cites W2146752377 @default.
• W2020671115 cites W2161792071 @default.
• W2020671115 cites W2170234279 @default.
• W2020671115 cites W2171045789 @default.
• W2020671115 cites W2317145780 @default.
• W2020671115 doi "https://doi.org/10.1002/ibd.21893" @default.
• W2020671115 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21987473" @default.
• W2020671115 hasPublicationYear "2012" @default.
• W2020671115 type Work @default.
• W2020671115 sameAs 2020671115 @default.
• W2020671115 citedByCount "29" @default.
• W2020671115 countsByYear W20206711152012 @default.
• W2020671115 countsByYear W20206711152013 @default.
• W2020671115 countsByYear W20206711152014 @default.
• W2020671115 countsByYear W20206711152015 @default.
• W2020671115 countsByYear W20206711152016 @default.
• W2020671115 countsByYear W20206711152017 @default.
• W2020671115 countsByYear W20206711152018 @default.
• W2020671115 countsByYear W20206711152019 @default.
• W2020671115 countsByYear W20206711152021 @default.
• W2020671115 countsByYear W20206711152023 @default.
• W2020671115 crossrefType "journal-article" @default.
• W2020671115 hasAuthorship W2020671115A5003478464 @default.
• W2020671115 hasAuthorship W2020671115A5005523458 @default.
• W2020671115 hasAuthorship W2020671115A5011038778 @default.
• W2020671115 hasAuthorship W2020671115A5040981628 @default.
• W2020671115 hasAuthorship W2020671115A5048213341 @default.
• W2020671115 hasAuthorship W2020671115A5054069732 @default.
• W2020671115 hasAuthorship W2020671115A5061019212 @default.
• W2020671115 hasAuthorship W2020671115A5064125430 @default.
• W2020671115 hasAuthorship W2020671115A5073349527 @default.
• W2020671115 hasAuthorship W2020671115A5075268369 @default.
• W2020671115 hasAuthorship W2020671115A5086629019 @default.
• W2020671115 hasBestOaLocation W20206711151 @default.
• W2020671115 hasConcept C104317684 @default.
• W2020671115 hasConcept C127716648 @default.
• W2020671115 hasConcept C151872237 @default.
• W2020671115 hasConcept C18903297 @default.
• W2020671115 hasConcept C203014093 @default.
• W2020671115 hasConcept C2776090121 @default.

• next