Matches in SemOpenAlex for { <https://semopenalex.org/work/W2020672242> ?p ?o ?g. }
- W2020672242 endingPage "430" @default.
- W2020672242 startingPage "405" @default.
- W2020672242 abstract "There is a growing body of literature detailing the endocrine consequences of cancer therapy. Certain conclusions can be drawn from the data presented. Patients who have received incidental hypothalamic--pituitary gland irradiation need to be followed carefully with serial dynamic hormonal evaluations, as they are at high risk of developing growth hormone and prolactin abnormalities and can develop other pituitary tropic hormone deficiencies as well. Children especially should be monitored closely as GH deficiency can be corrected if detected early. Patients who have received radiation to the head and neck region will need long-term (up to 30 years) surveillance for the development of thyroid cancer, hyperparathyroidism or hypothyroidism. Persistent elevations of TSH after incidental thyroidal irradiation are frequently seen and should be reversed with thyroid hormone administration in an attempt to minimize TSH stimulation of the irradiated gland. Radiation to the gonads will cause graded damage dependent on the dose delivered and the mode of fractionation. Age in a woman seems to be a significant factor of radiation sensitivity. Certain chemotherapeutic agents are radiomimetic in their gonadal effects; to date the alkylating agents have been most commonly implicated. FSH elevations herald gonadal damage (aspermia or loss of follicles) and should be looked for in patients receiving abdominal radiation or systemic chemotherapy. Leydig cell dysfunction occurs less frequently. Of all the iatrogenic endocrine complications discussed, some are eminently treatable, and some are quite preventable. Greater awareness of the unexpectedly high incidence of hormonal dysfunction can help lessen therapy-induced morbidity in long-term cancer survivors." @default.
- W2020672242 created "2016-06-24" @default.
- W2020672242 creator A5008864286 @default.
- W2020672242 date "1980-07-01" @default.
- W2020672242 modified "2023-10-18" @default.
- W2020672242 title "Disorders of endocrine function following cancer therapies" @default.
- W2020672242 cites W1489726538 @default.
- W2020672242 cites W1518822855 @default.
- W2020672242 cites W1546235520 @default.
- W2020672242 cites W1557379412 @default.
- W2020672242 cites W1589147909 @default.
- W2020672242 cites W185711167 @default.
- W2020672242 cites W1943232464 @default.
- W2020672242 cites W1965603638 @default.
- W2020672242 cites W1966332430 @default.
- W2020672242 cites W1967612457 @default.
- W2020672242 cites W1971639854 @default.
- W2020672242 cites W1974141391 @default.
- W2020672242 cites W1976644862 @default.
- W2020672242 cites W1978041074 @default.
- W2020672242 cites W1978905312 @default.
- W2020672242 cites W1979911737 @default.
- W2020672242 cites W1981367389 @default.
- W2020672242 cites W1983700509 @default.
- W2020672242 cites W1985438597 @default.
- W2020672242 cites W1985927097 @default.
- W2020672242 cites W1986072887 @default.
- W2020672242 cites W1987831206 @default.
- W2020672242 cites W1987848801 @default.
- W2020672242 cites W1988102255 @default.
- W2020672242 cites W1988783532 @default.
- W2020672242 cites W1989175401 @default.
- W2020672242 cites W1994121260 @default.
- W2020672242 cites W1999338517 @default.
- W2020672242 cites W2003425504 @default.
- W2020672242 cites W2004521925 @default.
- W2020672242 cites W2005463875 @default.
- W2020672242 cites W2008148951 @default.
- W2020672242 cites W2011021508 @default.
- W2020672242 cites W2011137032 @default.
- W2020672242 cites W2019600412 @default.
- W2020672242 cites W2021237102 @default.
- W2020672242 cites W2021616554 @default.
- W2020672242 cites W2024952105 @default.
- W2020672242 cites W2025884890 @default.
- W2020672242 cites W2026174876 @default.
- W2020672242 cites W2026935794 @default.
- W2020672242 cites W2027411321 @default.
- W2020672242 cites W2031321160 @default.
- W2020672242 cites W2034013897 @default.
- W2020672242 cites W2034172400 @default.
- W2020672242 cites W2035551059 @default.
- W2020672242 cites W2040840932 @default.
- W2020672242 cites W2041121271 @default.
- W2020672242 cites W2041243312 @default.
- W2020672242 cites W2042386328 @default.
- W2020672242 cites W2042685832 @default.
- W2020672242 cites W2048092955 @default.
- W2020672242 cites W2049552282 @default.
- W2020672242 cites W2049834847 @default.
- W2020672242 cites W2052866457 @default.
- W2020672242 cites W2055032782 @default.
- W2020672242 cites W2055085748 @default.
- W2020672242 cites W2056524014 @default.
- W2020672242 cites W2058650437 @default.
- W2020672242 cites W2058655763 @default.
- W2020672242 cites W2062829697 @default.
- W2020672242 cites W2065095422 @default.
- W2020672242 cites W2068387173 @default.
- W2020672242 cites W2070180680 @default.
- W2020672242 cites W2072339309 @default.
- W2020672242 cites W2072847808 @default.
- W2020672242 cites W2075036505 @default.
- W2020672242 cites W2081065388 @default.
- W2020672242 cites W2082733265 @default.
- W2020672242 cites W2083297559 @default.
- W2020672242 cites W2084291687 @default.
- W2020672242 cites W2084858917 @default.
- W2020672242 cites W2091836948 @default.
- W2020672242 cites W2093891508 @default.
- W2020672242 cites W2096605735 @default.
- W2020672242 cites W2104604416 @default.
- W2020672242 cites W2108367092 @default.
- W2020672242 cites W2131676374 @default.
- W2020672242 cites W2134422076 @default.
- W2020672242 cites W2135231000 @default.
- W2020672242 cites W2151716122 @default.
- W2020672242 cites W2162388356 @default.
- W2020672242 cites W2222668813 @default.
- W2020672242 cites W2316402011 @default.
- W2020672242 cites W2334984195 @default.
- W2020672242 cites W2335138225 @default.
- W2020672242 cites W2335332412 @default.
- W2020672242 cites W2337242335 @default.
- W2020672242 cites W2340377279 @default.
- W2020672242 cites W2398736666 @default.
- W2020672242 cites W2415815244 @default.
- W2020672242 cites W2416673575 @default.