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- W2020674003 abstract "Background and Objectives Clinical trials increasingly use results of diagnostic tests as surrogate outcomes. Our objective was to answer the following questions: (1) is the parameter measured by the reference standard a valid surrogate? (2) How does the tests accuracy influence the estimate of the treatment benefit on surrogate? (3) Is it possible to correct the measured treatment effect given by results of inaccurate tests? Methods and Setting We reviewed the literature on asymptomatic deep venous thrombosis (DVT), detected by the reference standard and other imaging techniques, as surrogate for venous thromboembolism. The influence of test inaccuracy on the measurement of treatment benefit was calculated as a function of the patient baseline risk, the treatment effect model, and test performances. Results We show that: (1) asymptomatic DVT is correlated with clinical outcomes but is yet to be established as a surrogate; (2) inaccurate diagnostic test underestimates the treatment effect on surrogate; (3) the prevalence of the disease, the treatment effect model, and the accuracy of the test and the reference standard used to evaluate it need to be known to correct this underestimation. Conclusion Even when the surrogate end point is valid, without a reliable study of the diagnostic test we cannot quantify the true treatment effect." @default.
- W2020674003 created "2016-06-24" @default.
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- W2020674003 date "2005-10-01" @default.
- W2020674003 modified "2023-10-17" @default.
- W2020674003 title "The true treatment benefit is unpredictable in clinical trials using surrogate outcome measured with diagnostic tests" @default.
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- W2020674003 cites W1732825167 @default.
- W2020674003 cites W1841440572 @default.
- W2020674003 cites W1892539883 @default.
- W2020674003 cites W1916215700 @default.
- W2020674003 cites W1923523575 @default.
- W2020674003 cites W1964211461 @default.
- W2020674003 cites W1970149092 @default.
- W2020674003 cites W1971348077 @default.
- W2020674003 cites W1980140122 @default.
- W2020674003 cites W1980669153 @default.
- W2020674003 cites W1981403806 @default.
- W2020674003 cites W1992894877 @default.
- W2020674003 cites W1995208791 @default.
- W2020674003 cites W1997022625 @default.
- W2020674003 cites W2000139681 @default.
- W2020674003 cites W2010599049 @default.
- W2020674003 cites W2016022016 @default.
- W2020674003 cites W2026103263 @default.
- W2020674003 cites W2028892722 @default.
- W2020674003 cites W2046499926 @default.
- W2020674003 cites W2050681327 @default.
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- W2020674003 cites W2066701117 @default.
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- W2020674003 cites W2115980766 @default.
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- W2020674003 doi "https://doi.org/10.1016/j.jclinepi.2005.02.024" @default.
- W2020674003 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2670365" @default.
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