Matches in SemOpenAlex for { <https://semopenalex.org/work/W2020679970> ?p ?o ?g. }
- W2020679970 endingPage "1930" @default.
- W2020679970 startingPage "1914" @default.
- W2020679970 abstract "DNA methyltransferases--DNMT1, DNMT3a, and DNMT3b--produce methylation patterns that dynamically regulate chromatin remodeling and gene expression. The vertebrate retina provides an ideal model to elucidate molecular control of neurogenesis as all neuronal cell types and Müller glia are generated in a conserved order from common pools of progenitor cells. As a prelude to exploring epigenetic regulation of mammalian retinal development, we investigated the expression of Dnmt1, Dnmt3a, and Dnmt3b in the mouse retina from embryonic day (E) 10.5 to 10 months of age. High levels of transcripts for all three Dnmt genes were observed in early stages of retinal differentiation, with significantly reduced expression after birth. Although DNMT1 protein is abundant in retinal progenitors at E10.5, it becomes restricted to postmitotic cells by E15.5. Most cells in the postnatal retina show nuclear immunostaining of DNMT1; however, the photoreceptors exhibit distinctive patterns. In rods, weak expression of DNMT1 is detected in perinuclear region and in the nucleus, whereas a strong nuclear labeling is evident in cones. DNMT3a and DNMT3b show a discrete pattern in developing retina with high expression at E11.5, little or no immunostaining by E15.5, and then postnatal expression overlapping with DNMT1 in early born neurons (ganglion, amacrine and horizontal cells, and cones). Robust nuclear localization of DNMTs in cones compared to rods suggests a potential role of DNA methylation in differential remodeling of chromatin in these two specialized neurons. Our studies indicate that DNA methyltransferases contribute to the establishment and maturation of cell fates during retinal development." @default.
- W2020679970 created "2016-06-24" @default.
- W2020679970 creator A5007910838 @default.
- W2020679970 creator A5050544784 @default.
- W2020679970 creator A5059151872 @default.
- W2020679970 creator A5071084848 @default.
- W2020679970 creator A5075837423 @default.
- W2020679970 creator A5086069301 @default.
- W2020679970 date "2011-05-23" @default.
- W2020679970 modified "2023-10-01" @default.
- W2020679970 title "Distinct nuclear localization patterns of DNA methyltransferases in developing and mature mammalian retina" @default.
- W2020679970 cites W1488115555 @default.
- W2020679970 cites W1494290222 @default.
- W2020679970 cites W1508625050 @default.
- W2020679970 cites W1525882285 @default.
- W2020679970 cites W1577875429 @default.
- W2020679970 cites W1963825294 @default.
- W2020679970 cites W1966608076 @default.
- W2020679970 cites W1967064280 @default.
- W2020679970 cites W1967195106 @default.
- W2020679970 cites W1968127700 @default.
- W2020679970 cites W1968800607 @default.
- W2020679970 cites W1969830087 @default.
- W2020679970 cites W1975389085 @default.
- W2020679970 cites W1975477048 @default.
- W2020679970 cites W1976626368 @default.
- W2020679970 cites W1981968179 @default.
- W2020679970 cites W1985102214 @default.
- W2020679970 cites W1985650850 @default.
- W2020679970 cites W1986674919 @default.
- W2020679970 cites W1988623932 @default.
- W2020679970 cites W1992613521 @default.
- W2020679970 cites W1998937707 @default.
- W2020679970 cites W2000261005 @default.
- W2020679970 cites W2000519327 @default.
- W2020679970 cites W2004078197 @default.
- W2020679970 cites W2004172747 @default.
- W2020679970 cites W2008920115 @default.
- W2020679970 cites W2009744628 @default.
- W2020679970 cites W2012155741 @default.
- W2020679970 cites W2012860082 @default.
- W2020679970 cites W2013393348 @default.
- W2020679970 cites W2016508121 @default.
- W2020679970 cites W2019071873 @default.
- W2020679970 cites W2020246476 @default.
- W2020679970 cites W2025297276 @default.
- W2020679970 cites W2027753607 @default.
- W2020679970 cites W2028444154 @default.
- W2020679970 cites W2028835848 @default.
- W2020679970 cites W2032917789 @default.
- W2020679970 cites W2033585891 @default.
- W2020679970 cites W2041299611 @default.
- W2020679970 cites W2041598409 @default.
- W2020679970 cites W2042668454 @default.
- W2020679970 cites W2045708955 @default.
- W2020679970 cites W2046241907 @default.
- W2020679970 cites W2046681118 @default.
- W2020679970 cites W2047999602 @default.
- W2020679970 cites W2050384954 @default.
- W2020679970 cites W2053901332 @default.
- W2020679970 cites W2057089696 @default.
- W2020679970 cites W2060446375 @default.
- W2020679970 cites W2062808446 @default.
- W2020679970 cites W2064943181 @default.
- W2020679970 cites W2067470032 @default.
- W2020679970 cites W2071138514 @default.
- W2020679970 cites W2072806829 @default.
- W2020679970 cites W2073507253 @default.
- W2020679970 cites W2075365540 @default.
- W2020679970 cites W2075432652 @default.
- W2020679970 cites W2077562677 @default.
- W2020679970 cites W2081195534 @default.
- W2020679970 cites W2081291827 @default.
- W2020679970 cites W2084355089 @default.
- W2020679970 cites W2088237277 @default.
- W2020679970 cites W2089013147 @default.
- W2020679970 cites W2093289593 @default.
- W2020679970 cites W2097974081 @default.
- W2020679970 cites W2100325414 @default.
- W2020679970 cites W2103851277 @default.
- W2020679970 cites W2106622947 @default.
- W2020679970 cites W2107498593 @default.
- W2020679970 cites W2107749421 @default.
- W2020679970 cites W2114570899 @default.
- W2020679970 cites W2116810261 @default.
- W2020679970 cites W2116869556 @default.
- W2020679970 cites W2122381170 @default.
- W2020679970 cites W2126486896 @default.
- W2020679970 cites W2131905274 @default.
- W2020679970 cites W2136801447 @default.
- W2020679970 cites W2136899592 @default.
- W2020679970 cites W2137296349 @default.
- W2020679970 cites W2141554152 @default.
- W2020679970 cites W2141963489 @default.
- W2020679970 cites W2149790281 @default.
- W2020679970 cites W2154536753 @default.
- W2020679970 cites W2157191738 @default.
- W2020679970 cites W2158625231 @default.