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• W2020692022 endingPage "90" @default.
• W2020692022 startingPage "84" @default.
• W2020692022 abstract "Doping with growth hormone (GH) is banned; however, there is anecdotal evidence that it is widely abused. GH is reportedly often used in combination with anabolic steroids at high doses for several months. Development of a robust test for detecting GH has been challenging since recombinant human 22-kDa GH used in doping is indistinguishable analytically from endogenous GH and there are wide physiological fluctuations in circulating GH concentrations.One approach to GH testing is based on measurement of different circulating GH isoforms using immunoassays that differentiate between 22-kDa and other GH isoforms. Administration of 22-kDa GH results in a change in its abundance relative to other endogenous pituitary GH isoforms. The differential isoform method is, however, limited by its short time window of detection. A second approach that extends the time window of detection is based on detection of increased levels of circulating GH-responsive proteins, such as the insulin-like growth factor (IGF) axis and collagen peptides. As age and gender are the major determinants of variability for IGF-I and the collagen markers, a test based on these markers must take these factors into account. Extensive data now validate the GH-responsive marker approach, and implementation is largely dependent on establishing an assured supply of standardized assays.Robust tests are available to detect GH and enforce the ban on its abuse in sports. Novel approaches that include gene expression and proteomic profiling must continue to be pursued to expand the repertoire of testing approaches available and to maintain deterrence of GH doping." @default.
• W2020692022 created "2016-06-24" @default.
• W2020692022 creator A5048743050 @default.
• W2020692022 creator A5050397488 @default.
• W2020692022 date "2011-01-01" @default.
• W2020692022 modified "2023-09-27" @default.
• W2020692022 title "Growth Hormone in Sports: Detecting the Doped or Duped" @default.
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• W2020692022 doi "https://doi.org/10.1159/000329185" @default.
• W2020692022 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21778756" @default.
• W2020692022 hasPublicationYear "2011" @default.
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