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- W2020695000 abstract "Carotid intima media thickness (CIMT) is clearly associated with atherosclerosis. Studies in ischemic stroke patients reveal that there is a significant association between CIMT with monocyte chemoattractant protein-1 (MCP-1) and osteopontin (OPN) promoter polymorphism. This research aims to explain the effect of MCP-1 and OPN promoter polymorphism toward CIMT changes identified in Javanese Indonesian children. Subjects were 54 children: 27 were from parents with ischemic stroke (cases), and 27 were from healthy parents (controlled). The CIMT was examined by utilizing high resolution B-mode ultrasound. Physical examination and genotyping analysis of MCP-1 promoter were conducted by employing PCR method. Research results indicate that two polymorphisms were obtained, that is, A-2138T and G-2464A, respectively. A-2138T polymorphism was found in 5% of case children and in 14.3% of controlled children. G-2464A polymorphism was found in 5% of case children. CIMT of case children was significantly different from that of controlled children (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M1><mml:mn>0.61</mml:mn><mml:mo>±</mml:mo><mml:mn>0.012</mml:mn></mml:math> mm versus,<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M2><mml:mn>0.52</mml:mn><mml:mo>±</mml:mo><mml:mn>0.015</mml:mn></mml:math> mm,<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M3><mml:mi>P</mml:mi><mml:mo>=</mml:mo></mml:math>0.021). Subjects with MCP-1 promoter polymorphism have 1.471 times higher tendency to have thicker CIMT than subjects with no polymorphism in MCP1 promoter. OPN promoter T-66G was also studied but it did not indicate occurrence of polymorphism in samples." @default.
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- W2020695000 date "2014-01-01" @default.
- W2020695000 modified "2023-10-14" @default.
- W2020695000 title "Thicker Carotid Intima Media Thickness in Children with Monocyte Chemoattractant Protein-1: A-2138T and A-2464G Mutation" @default.
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- W2020695000 doi "https://doi.org/10.1155/2014/176535" @default.
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