FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2020696972> ?p ?o ?g. }

• W2020696972 endingPage "62" @default.
• W2020696972 startingPage "52" @default.
• W2020696972 abstract "The distribution of ryanodine receptor (RyR) isoforms was examined using isoform-specific monoclonal antibodies in the developing chicken brain, from E18 through adulthood, using light and electron microscopic immunocytochemistry. Monoclonal antibody 110F is specific for the alpha-skeletal muscle form of RyR, while monoclonal antibody 110E recognizes both the beta-skeletal muscle and cardiac isoforms, but does not distinguish between the two. Significant differences in the distribution of the alpha- and beta/cardiac forms were observed. Labeling for the alpha-form was restricted to cerebellar Purkinje neurons while the beta/cardiac form was observed in neurons throughout the brain. A major finding was the presence of labeling for the beta/cardiac in presynaptic terminals of the parallel fibers in the molecular layer and the mossy fiber terminals in the granular layer glomeruli in late development and during adulthood. Labeling for the beta/cardiac, but not the alpha-form, underwent a major redistribution in the cerebellum during the course of development. At 1 day of age, beta/cardiac labeling was present mainly in Purkinje neurons. From 1 day to 4 weeks, immunolabeling for the beta/cardiac form gradually disappeared from Purkinje neurons, but increased in granule cells. Within the molecular layer, the labeling pattern changed from being primarily within Purkinje dendrites to a more diffuse pattern. Electron microscopic examination of the cerebellar molecular layer of 2-week-old chicks revealed that beta/cardiac-labeling was mainly present in the axons and presynaptic processes of the parallel fibers. No developmental changes were observed in other brain regions. This study represents the first demonstration of ryanodine receptor immunoreactivity in presynaptic boutons and suggests that the ryanodine receptor may modulate neurotransmitter release through local regulation of intracellular calcium in the parallel fiber synapse." @default.
• W2020696972 created "2016-06-24" @default.
• W2020696972 creator A5027087494 @default.
• W2020696972 creator A5051156147 @default.
• W2020696972 creator A5053851229 @default.
• W2020696972 creator A5061037631 @default.
• W2020696972 creator A5076820440 @default.
• W2020696972 creator A5084271294 @default.
• W2020696972 date "1997-11-01" @default.
• W2020696972 modified "2023-09-24" @default.
• W2020696972 title "Differential distribution and subcellular localization of ryanodine receptor isoforms in the chicken cerebellum during development" @default.
• W2020696972 cites W12635643 @default.
• W2020696972 cites W1483833346 @default.
• W2020696972 cites W1490746554 @default.
• W2020696972 cites W1525891657 @default.
• W2020696972 cites W1560226916 @default.
• W2020696972 cites W1561980328 @default.
• W2020696972 cites W1567815552 @default.
• W2020696972 cites W1589881202 @default.
• W2020696972 cites W1641967096 @default.
• W2020696972 cites W1820758986 @default.
• W2020696972 cites W1876995878 @default.
• W2020696972 cites W1940983842 @default.
• W2020696972 cites W1952906612 @default.
• W2020696972 cites W1965290060 @default.
• W2020696972 cites W1974143212 @default.
• W2020696972 cites W1975791710 @default.
• W2020696972 cites W1976841908 @default.
• W2020696972 cites W1982594839 @default.
• W2020696972 cites W1990616763 @default.
• W2020696972 cites W1997940952 @default.
• W2020696972 cites W2005706099 @default.
• W2020696972 cites W2008305923 @default.
• W2020696972 cites W2014030164 @default.
• W2020696972 cites W2017176650 @default.
• W2020696972 cites W2017826010 @default.
• W2020696972 cites W2021515748 @default.
• W2020696972 cites W2023916352 @default.
• W2020696972 cites W2037744654 @default.
• W2020696972 cites W2039443079 @default.
• W2020696972 cites W2039547987 @default.
• W2020696972 cites W2046786443 @default.
• W2020696972 cites W2049663850 @default.
• W2020696972 cites W2052739933 @default.
• W2020696972 cites W2052768287 @default.
• W2020696972 cites W2052830287 @default.
• W2020696972 cites W2057858723 @default.
• W2020696972 cites W2058984027 @default.
• W2020696972 cites W2067297047 @default.
• W2020696972 cites W2074890054 @default.
• W2020696972 cites W2079810936 @default.
• W2020696972 cites W2085326980 @default.
• W2020696972 cites W2088084975 @default.
• W2020696972 cites W2099387884 @default.
• W2020696972 cites W2111653630 @default.
• W2020696972 cites W2123384023 @default.
• W2020696972 cites W2128010947 @default.
• W2020696972 cites W2128113643 @default.
• W2020696972 cites W2140685580 @default.
• W2020696972 cites W2155883881 @default.
• W2020696972 cites W2161957047 @default.
• W2020696972 cites W2172295889 @default.
• W2020696972 cites W2235943107 @default.
• W2020696972 cites W2339216564 @default.
• W2020696972 cites W2395349312 @default.
• W2020696972 cites W2396474005 @default.
• W2020696972 cites W4245552230 @default.
• W2020696972 cites W964655812 @default.
• W2020696972 doi "https://doi.org/10.1016/s0006-8993(97)00840-8" @default.
• W2020696972 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9439828" @default.
• W2020696972 hasPublicationYear "1997" @default.
• W2020696972 type Work @default.
• W2020696972 sameAs 2020696972 @default.
• W2020696972 citedByCount "23" @default.
• W2020696972 countsByYear W20206969722013 @default.
• W2020696972 countsByYear W20206969722021 @default.
• W2020696972 crossrefType "journal-article" @default.
• W2020696972 hasAuthorship W2020696972A5027087494 @default.
• W2020696972 hasAuthorship W2020696972A5051156147 @default.
• W2020696972 hasAuthorship W2020696972A5053851229 @default.
• W2020696972 hasAuthorship W2020696972A5061037631 @default.
• W2020696972 hasAuthorship W2020696972A5076820440 @default.
• W2020696972 hasAuthorship W2020696972A5084271294 @default.
• W2020696972 hasConcept C104317684 @default.
• W2020696972 hasConcept C113217602 @default.
• W2020696972 hasConcept C134018914 @default.
• W2020696972 hasConcept C158617107 @default.
• W2020696972 hasConcept C169760540 @default.
• W2020696972 hasConcept C203014093 @default.
• W2020696972 hasConcept C204232928 @default.
• W2020696972 hasConcept C2776464000 @default.
• W2020696972 hasConcept C2777318268 @default.
• W2020696972 hasConcept C2777877921 @default.
• W2020696972 hasConcept C2778058767 @default.
• W2020696972 hasConcept C2778472085 @default.
• W2020696972 hasConcept C2778888523 @default.
• W2020696972 hasConcept C2778996579 @default.
• W2020696972 hasConcept C2779652256 @default.

• next