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- W2020699084 abstract "Mutations in the Drosophila retinal degeneration A (rdgA) gene, which encodes diacylglycerol kinase (DGK), result in early onset retinal degeneration and blindness. Whole-cell recordings revealed that light-sensitive Ca2+ channels encoded by the trp gene were constitutively active in rdgA photoreceptors. Early degeneration was rescued in rdgA;trp double mutants, lacking TRP channels; however, the less Ca2+-permeable light-sensitive channels (TRPL) were constitutively active instead. No constitutive activity was seen in rdgA;trpl;trp mutants lacking both classes of channel, although, like rdgA;trp, these still showed a residual slow degeneration. Responses to light were restored in rdgA;trp but deactivated abnormally slowly, indicating that DGK is required for response termination. The findings suggest that early degeneration in rdgA is caused by uncontrolled Ca2+ influx and support the proposal that diacylglycerol or its metabolites are messengers of excitation in Drosophila photoreceptors." @default.
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- W2020699084 date "2000-04-01" @default.
- W2020699084 modified "2023-10-17" @default.
- W2020699084 title "Constitutive Activity of the Light-Sensitive Channels TRP and TRPL in the Drosophila Diacylglycerol Kinase Mutant, rdgA" @default.
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- W2020699084 doi "https://doi.org/10.1016/s0896-6273(00)81147-2" @default.
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