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- W2020705418 abstract "Abstract The first direct asymmetric synthetic preparation of trifluoro‐1‐(indol‐3‐yl)ethanols (TFIEs) is described by an enantioselective organocatalytic method from indoles and inexpensive trifluoroacetaldehyde methyl hemiacetal. The reaction is catalyzed by hydroquinine to produce TFIEs in an almost quantitative yield and with enantioselectivities up to 75% at room temperature. The enantioselectivity is strongly dependent on the concentration of substrates and catalyst due to the competitive noncatalyzed reaction. Chirality, 2011. © 2011 Wiley‐Liss, Inc." @default.
- W2020705418 created "2016-06-24" @default.
- W2020705418 creator A5034916482 @default.
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- W2020705418 date "2011-07-11" @default.
- W2020705418 modified "2023-10-16" @default.
- W2020705418 title "Enantioselective Friedel-Crafts reaction of indoles with trifluoroacetaldehyde catalyzed by Cinchona alkaloids" @default.
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- W2020705418 doi "https://doi.org/10.1002/chir.20982" @default.
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