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- W2020707144 abstract "El asma infantil es una enfermedad inflamatoria heterogénea con diferentes fenotipos (con sibilancias transitorias, no atópicos, atópicos y obesos) y diferente expresión clínica y multifactorial, pero que siguen una vía común, caracterizada por cuadros recurrentes de obstrucción de la vía aérea. Se ha demostrado que la inmensa mayoría de asmáticos comienza su enfermedad en los primeros años de vida, que la inflamación y la remodelación de la vía aérea están ya presentes en escolares asmáticos e incluso que hay inflamación en lactantes con sibilancias persistentes. El problema consiste en identificar tempranamente qué lactante con sibilancias recurrentes tiene riesgo de presentar posteriormente asma persistente. Se postula el uso del Algoritmo Predictor de Asma (Asthma Predictive Index), que es una herramienta simple, validada en estudios longitudinales y que nos permite identificar tempranamente ese fenotipo de lactantes sibilantes (cuya función pulmonar presenta su principal deterioro irreversible en los primeros años de vida) con riesgo de desarrollar asma. Childhood asthma is a heterogeneous inflammatory disease with several wheezing phenotypes (transient, atopic, nonatopic, and obese) and various clinical expressions of multifactorial origin. All forms, however, follow a similar course characterized by recurrent episodes of airway obstruction. Studies have shown that the onset of disease occurs early in life for the great majority of asthmatics, that airway inflammation and remodeling are present in schoolchildren with asthma, and that even infants with persistent wheezing present airway inflammation. The difficulty lies in the early identification of infants with recurrent wheezing who are at risk of suffering persistent asthma later in life. The Asthma Predictive Index, a simple tool validated in a longitudinal study, has been suggested for early identification of infants with recurrent wheezing who are at risk of developing asthma and whose lung function has undergone major irreversible damage during the first years of life." @default.
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- W2020707144 title "¿Cómo evaluar el riesgo de asma bronquial en lactantes y preescolares?" @default.
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- W2020707144 doi "https://doi.org/10.1157/13092416" @default.
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