FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2020709354> ?p ?o ?g. }

• W2020709354 endingPage "151" @default.
• W2020709354 startingPage "138" @default.
• W2020709354 abstract "Amyotrophic lateral sclerosis (ALS) is characterized by the selective death of motor neurons in the motor cortex, brainstem and spinal cord. It is a neurodegenerative disorder with high genetic and phenotypic variability. In most patients, the cause of the disease is unknown. Until now, no treatment strategy has been discovered with the exception of riluzole which has a moderate effect on the disease process. While developing a new causal therapy targeting a specific disease-causing gene can have a huge effect on the disease process, only a limited number of ALS patients will benefit from such a therapy. Alternatively, pathogenic processes that are common in ALS patients with different etiology can also be targeted. The effect of such a modifying treatment will be smaller, but the target population will be larger as more ALS patients could benefit. In this review, we summarize the evidence for the involvement of different biological processes in the pathogenesis of ALS and will discuss how strategies influencing these processes can be translated into new therapeutic approaches. In order to further improve this translational step, there is an urgent need for a better understanding of the underlying mechanism(s), for new ALS animal models and for rigorous protocols to perform preclinical studies." @default.
• W2020709354 created "2016-06-24" @default.
• W2020709354 creator A5000942200 @default.
• W2020709354 creator A5024575812 @default.
• W2020709354 creator A5069828577 @default.
• W2020709354 creator A5076198690 @default.
• W2020709354 date "2014-12-01" @default.
• W2020709354 modified "2023-09-24" @default.
• W2020709354 title "Translating biological findings into new treatment strategies for amyotrophic lateral sclerosis (ALS)" @default.
• W2020709354 cites W1894493322 @default.
• W2020709354 cites W1915809219 @default.
• W2020709354 cites W1927539495 @default.
• W2020709354 cites W1940519961 @default.
• W2020709354 cites W1963646113 @default.
• W2020709354 cites W1964612353 @default.
• W2020709354 cites W1965558349 @default.
• W2020709354 cites W1966008881 @default.
• W2020709354 cites W1967752630 @default.
• W2020709354 cites W1969024031 @default.
• W2020709354 cites W1969850018 @default.
• W2020709354 cites W1970034329 @default.
• W2020709354 cites W1971386958 @default.
• W2020709354 cites W1971397654 @default.
• W2020709354 cites W1972571151 @default.
• W2020709354 cites W1972760525 @default.
• W2020709354 cites W1973610175 @default.
• W2020709354 cites W1974961961 @default.
• W2020709354 cites W1976266513 @default.
• W2020709354 cites W1976302347 @default.
• W2020709354 cites W1976371324 @default.
• W2020709354 cites W1979837223 @default.
• W2020709354 cites W1980165165 @default.
• W2020709354 cites W1982831764 @default.
• W2020709354 cites W1983564332 @default.
• W2020709354 cites W1984038309 @default.
• W2020709354 cites W1984538960 @default.
• W2020709354 cites W1984993201 @default.
• W2020709354 cites W1985403672 @default.
• W2020709354 cites W1987138690 @default.
• W2020709354 cites W1987495527 @default.
• W2020709354 cites W1989741374 @default.
• W2020709354 cites W1993064034 @default.
• W2020709354 cites W1993354361 @default.
• W2020709354 cites W1994350510 @default.
• W2020709354 cites W1995061803 @default.
• W2020709354 cites W1999283564 @default.
• W2020709354 cites W1999638129 @default.
• W2020709354 cites W2002104055 @default.
• W2020709354 cites W2002836409 @default.
• W2020709354 cites W2003163518 @default.
• W2020709354 cites W2003618511 @default.
• W2020709354 cites W2005927762 @default.
• W2020709354 cites W2006524711 @default.
• W2020709354 cites W2008092479 @default.
• W2020709354 cites W2009976415 @default.
• W2020709354 cites W2011142100 @default.
• W2020709354 cites W2013473672 @default.
• W2020709354 cites W2013516011 @default.
• W2020709354 cites W2016332933 @default.
• W2020709354 cites W2017808415 @default.
• W2020709354 cites W2018188434 @default.
• W2020709354 cites W2019508044 @default.
• W2020709354 cites W2019706623 @default.
• W2020709354 cites W2020159880 @default.
• W2020709354 cites W2020850411 @default.
• W2020709354 cites W2021374516 @default.
• W2020709354 cites W2021710989 @default.
• W2020709354 cites W2022367303 @default.
• W2020709354 cites W2022812113 @default.
• W2020709354 cites W2031215649 @default.
• W2020709354 cites W2031700674 @default.
• W2020709354 cites W2033158384 @default.
• W2020709354 cites W2036483462 @default.
• W2020709354 cites W2037054844 @default.
• W2020709354 cites W2038811384 @default.
• W2020709354 cites W2040469179 @default.
• W2020709354 cites W2040891140 @default.
• W2020709354 cites W2041874266 @default.
• W2020709354 cites W2043291430 @default.
• W2020709354 cites W2047517574 @default.
• W2020709354 cites W2052896464 @default.
• W2020709354 cites W2053215139 @default.
• W2020709354 cites W2053272214 @default.
• W2020709354 cites W2054068057 @default.
• W2020709354 cites W2054173516 @default.
• W2020709354 cites W2054542675 @default.
• W2020709354 cites W2054588014 @default.
• W2020709354 cites W2055022577 @default.
• W2020709354 cites W2056692956 @default.
• W2020709354 cites W2057622844 @default.
• W2020709354 cites W2059355164 @default.
• W2020709354 cites W2063996210 @default.
• W2020709354 cites W2064640860 @default.
• W2020709354 cites W2064982871 @default.
• W2020709354 cites W2065771915 @default.
• W2020709354 cites W2066181470 @default.
• W2020709354 cites W2066388903 @default.
• W2020709354 cites W2066557327 @default.

• next