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• W2020711034 abstract "The understanding of bacterial meningitis has undergone a major revolution since the first description of epidemic meningitis with a purpuric rash in 1805 [1]. This was followed by further observations of meningococcemia and meningitis, culminating with the isolation of the major meningeal pathogens (Neisseria meningitidis, Streptococcus pneumoniae, and Haemophilus influenzae) in the last two decades of the nineteenth century. Initial treatment of bacterial meningitis in the early years of this century consisted of methods for removal of large volumes of cerebrospinal fluid (CSF) and/or direct CSF instillation of various substances such as dyes and enzymes. The first truly therapeutic modality was introduced by Simon Flexner in 1913 [2], utilizing systemic and intrathecal antimeningococcal antisera; this treatment reduced the mortality rate of meningococcal meningitis from about 80% to 30%. However, major advances in the therapy of bacterial meningitis followed the advent of antimicrobial therapy with the introduction of sulfanilamide, penicillin, and other agents (streptomycin, chloramphenicol) [3,4]. Despite further advances in antibiotic development, the morbidity and mortality from bacterial meningitis remains unacceptably high. In this review, we focus on use of specific antimicrobial agents in the treatment of bacterial meningitis, highlighting recent changes in resistance patterns of meningeal pathogens, and discuss advances in the patho-" @default.
• W2020711034 created "2016-06-24" @default.
• W2020711034 creator A5015730498 @default.
• W2020711034 creator A5016854710 @default.
• W2020711034 date "1991-01-01" @default.
• W2020711034 modified "2023-09-23" @default.
• W2020711034 title "Therapy of bacterial meningitis in children" @default.
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• W2020711034 doi "https://doi.org/10.1016/0924-8579(91)90004-w" @default.
• W2020711034 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18611496" @default.
• W2020711034 hasPublicationYear "1991" @default.
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