Matches in SemOpenAlex for { <https://semopenalex.org/work/W2020721036> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W2020721036 endingPage "423" @default.
- W2020721036 startingPage "415" @default.
- W2020721036 abstract "The contribution of adrenergic stimulation to the proarrhythmic effects of pinacidil (30μM), an opener of ATP-sensitive potassium channels (K+ATP), was tested in an isolated guinea-pig heart model of global ischemia (10 min) and reperfusion (10 min). None (0%) of the control hearts (n=10) elicited arrhythmias during ischemia or reperfusion. In the pinacidil-treated group, one heart (5%) experienced episodes of ventricular tachycardia (VT)/fibrillation (VF) during normoxia. During ischemia, 63% (12 out of 19) of pinacidil-treated hearts exhibited episodes of VT or VF. Hearts not in VT or VF (n=7) at the time of reperfusion, exhibited 71% VT and 43% VT/VF upon reperfusion. Proarrhythmic effects of pinacidil during ischemia or reperfusion were completely reversed by glyburide (n=9; 10μM), a K+ATPantagonist, or nadolol (n=9; 3μM), aβ-adrenergic antagonist. Isoproterenol (n=10; 50 nM), aβ-adrenergic agonist, induced a 20% incidence of ischemic VT and VF, and a 70% incidence of reperfusion VF, while methoxamine (n=10; 10μM), anα-adrenergic agonist, demonstrated little proarrhythmia (20% VT/VF at reperfusion only). Proarrhythmic effects of isoproterenol were reversed by nadolol, but not glyburide. Pinacidil caused a slight potentiation of tachycardia induced by a bolus injection of tyramine (30μg), an indirectly acting sympathomimetic, but bolus injections of pinacidil (100μg) had no effect on heart rate. Nisoxetine, a catecholamine uptake1 inhibitor, had no proarrhythmic effects when given alone. Catecholamine levels were reduced in pinacidil-treated hearts relative to vehicle-treated. In conclusion, it is suggested that the proarrhythmic effects of pinacidil following global ischemia and reperfusion in the isolated perfused guinea-pig heart appears to involve stimulation ofβ-adrenoceptors. These proarrhythmic effects of pinacidil do not appear to be mediated solely through direct opening of K+ATP, but rather through an indirect enhancement of catecholamine release." @default.
- W2020721036 created "2016-06-24" @default.
- W2020721036 creator A5002195234 @default.
- W2020721036 creator A5009301588 @default.
- W2020721036 creator A5030379197 @default.
- W2020721036 creator A5038928807 @default.
- W2020721036 creator A5070931667 @default.
- W2020721036 date "1998-02-01" @default.
- W2020721036 modified "2023-10-18" @default.
- W2020721036 title "Proarrhythmic Effects of Pinacidil are Partially Mediated Through Enhancement of Catecholamine Release in Isolated Perfused Guinea-pig Hearts" @default.
- W2020721036 doi "https://doi.org/10.1006/jmcc.1997.0605" @default.
- W2020721036 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9515018" @default.
- W2020721036 hasPublicationYear "1998" @default.
- W2020721036 type Work @default.
- W2020721036 sameAs 2020721036 @default.
- W2020721036 citedByCount "27" @default.
- W2020721036 countsByYear W20207210362013 @default.
- W2020721036 countsByYear W20207210362016 @default.
- W2020721036 countsByYear W20207210362017 @default.
- W2020721036 countsByYear W20207210362018 @default.
- W2020721036 countsByYear W20207210362021 @default.
- W2020721036 countsByYear W20207210362023 @default.
- W2020721036 crossrefType "journal-article" @default.
- W2020721036 hasAuthorship W2020721036A5002195234 @default.
- W2020721036 hasAuthorship W2020721036A5009301588 @default.
- W2020721036 hasAuthorship W2020721036A5030379197 @default.
- W2020721036 hasAuthorship W2020721036A5038928807 @default.
- W2020721036 hasAuthorship W2020721036A5070931667 @default.
- W2020721036 hasConcept C118441451 @default.
- W2020721036 hasConcept C126322002 @default.
- W2020721036 hasConcept C134018914 @default.
- W2020721036 hasConcept C164705383 @default.
- W2020721036 hasConcept C170493617 @default.
- W2020721036 hasConcept C2775894120 @default.
- W2020721036 hasConcept C2775984225 @default.
- W2020721036 hasConcept C2776256041 @default.
- W2020721036 hasConcept C2777008848 @default.
- W2020721036 hasConcept C2778151854 @default.
- W2020721036 hasConcept C2778938600 @default.
- W2020721036 hasConcept C2779768347 @default.
- W2020721036 hasConcept C2781005686 @default.
- W2020721036 hasConcept C42219234 @default.
- W2020721036 hasConcept C555293320 @default.
- W2020721036 hasConcept C71924100 @default.
- W2020721036 hasConceptScore W2020721036C118441451 @default.
- W2020721036 hasConceptScore W2020721036C126322002 @default.
- W2020721036 hasConceptScore W2020721036C134018914 @default.
- W2020721036 hasConceptScore W2020721036C164705383 @default.
- W2020721036 hasConceptScore W2020721036C170493617 @default.
- W2020721036 hasConceptScore W2020721036C2775894120 @default.
- W2020721036 hasConceptScore W2020721036C2775984225 @default.
- W2020721036 hasConceptScore W2020721036C2776256041 @default.
- W2020721036 hasConceptScore W2020721036C2777008848 @default.
- W2020721036 hasConceptScore W2020721036C2778151854 @default.
- W2020721036 hasConceptScore W2020721036C2778938600 @default.
- W2020721036 hasConceptScore W2020721036C2779768347 @default.
- W2020721036 hasConceptScore W2020721036C2781005686 @default.
- W2020721036 hasConceptScore W2020721036C42219234 @default.
- W2020721036 hasConceptScore W2020721036C555293320 @default.
- W2020721036 hasConceptScore W2020721036C71924100 @default.
- W2020721036 hasIssue "2" @default.
- W2020721036 hasLocation W20207210361 @default.
- W2020721036 hasLocation W20207210362 @default.
- W2020721036 hasOpenAccess W2020721036 @default.
- W2020721036 hasPrimaryLocation W20207210361 @default.
- W2020721036 hasRelatedWork W1963744077 @default.
- W2020721036 hasRelatedWork W1982606002 @default.
- W2020721036 hasRelatedWork W1984082863 @default.
- W2020721036 hasRelatedWork W2005543962 @default.
- W2020721036 hasRelatedWork W2022307479 @default.
- W2020721036 hasRelatedWork W2052857635 @default.
- W2020721036 hasRelatedWork W2057708424 @default.
- W2020721036 hasRelatedWork W2084158216 @default.
- W2020721036 hasRelatedWork W2148129911 @default.
- W2020721036 hasRelatedWork W4293559815 @default.
- W2020721036 hasVolume "30" @default.
- W2020721036 isParatext "false" @default.
- W2020721036 isRetracted "false" @default.
- W2020721036 magId "2020721036" @default.
- W2020721036 workType "article" @default.