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• W2020725427 abstract "This editorial refers to ‘Incidence and predictors of atrial fibrillation and its impact onlong-term survival in patients with supraventricular arrhythmias’ by C. Ozcan et al. , on page 16(10): 1508–1514. The relationship between atrial fibrillation (AF) and cavotricuspid isthmus (CTI)-dependent atrial flutter (AFL) has long been appreciated. The presence of common triggers and substrate, particularly in the context of structural heart disease with concomitant structural and electrical remodelling, helps explain why both arrhythmias are often seen together and considered two sides of the same coin. In fact, functional conduction block, especially along the crista terminalis, and slowed conduction allow the transition from multiple unstable wavefronts in AF to a single organized circuit in typical AFL.1,2 Likewise, the same triggers that initiate AF, often arising from the pulmonary veins, may also be the triggers for AFL, via transitional AF. The roles of AF and AFL in arrhythmia initiation and maintenance are not straightforward: AF can initiate AFL or organize to AFL, especially in patients taking antiarrhythmic drugs, but electrical remodelling caused by AFL may also serve as the substrate for subsequent AF occurrence.3The relationship between AF and other supraventricular arrhythmias (SVA) has not been addressed as thoroughly. However, electrical remodelling is not exclusive to AFL. The phrase ‘AF begets AF’ has been used to describe the pro-arrhythmic effect of prolonged rapid atrial rates. It is an established electrophysiological principle that atrial myocytes exhibit shortening of the action potential duration and effective refractory period with rapid atrial electrical activation. Atrial tachycardia (AT) induced electrical remodelling occurs both in the intact whole heart in vivo and in cultured atrial myocytes exposed to rapid stimulation.4 …" @default.
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• W2020725427 date "2014-12-04" @default.
• W2020725427 modified "2023-09-26" @default.
• W2020725427 title "Is atrial fibrillation so common after supraventricular arrhythmia ablation as to require prophylactic treatment?" @default.
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• W2020725427 doi "https://doi.org/10.1093/europace/euu315" @default.
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