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• W2020731023 startingPage "16141" @default.
• W2020731023 abstract "A method of DNA monolayer formation has been developed using copper-free click chemistry that yields enhanced surface homogeneity and enables variation in the amount of DNA assembled; extremely low-density DNA monolayers, with as little as 5% of the monolayer being DNA, have been formed. These DNA-modified electrodes (DMEs) were characterized visually, with AFM, and electrochemically, and were found to facilitate DNA-mediated reduction of a distally bound redox probe. These low-density monolayers were found to be more homogeneous than traditional thiol-modified DNA monolayers, with greater helix accessibility through an increased surface area-to-volume ratio. Protein binding efficiency of the transcriptional activator TATA-binding protein (TBP) was also investigated on these surfaces and compared to that on DNA monolayers formed with standard thiol-modified DNA. Our low-density monolayers were found to be extremely sensitive to TBP binding, with a signal decrease in excess of 75% for 150 nM protein. This protein was detectable at 4 nM, on the order of its dissociation constant, with our low-density monolayers. The improved DNA helix accessibility and sensitivity of our low-density DNA monolayers to TBP binding reflects the general utility of this method of DNA monolayer formation for DNA-based electrochemical sensor development." @default.
• W2020731023 created "2016-06-24" @default.
• W2020731023 creator A5010855228 @default.
• W2020731023 creator A5018653043 @default.
• W2020731023 creator A5045229256 @default.
• W2020731023 date "2013-12-11" @default.
• W2020731023 modified "2023-10-12" @default.
• W2020731023 title "DNA-Modified Electrodes Fabricated Using Copper-Free Click Chemistry for Enhanced Protein Detection" @default.
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• W2020731023 doi "https://doi.org/10.1021/la403262v" @default.
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