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- W2020733715 abstract "Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DCBackground Pantoparzole(PPZ) is a proton pump inhibitor which is known to have an apoptotic activity in gastric cancer cells. Meanshile, tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is known to induce apoptosis in cancer cells. However, some types of cancer cells, including AGS human gastric adenocarcinoma cells show resistance for the TRAIL-mediated apoptosis. This study was aimed to investigate the sensitizing effectcs of PPZ on TRAIL-mediated apoptosis in AGS cell line.Methods Sensitivity to TRAIL and activation of TRAIL-induced apoptotic pathways were analyzed in AGS cell lines. WST-1 method was used to evaluate cell viability; Western blots was used to evaluate TRAIL-induced apoptosis.Results TRAIL alone had little effect on apoptosis in AGS cells. However, treatment with TRAIL in combination with subtoxic concentrations of PPZ sensitized TRAIL-mediated apoptosis in AGS cells. Combined treatment of PPZ and TRAIL induced caspase(caspase-8, -9, -3) and the pro-apoptotic molecules (Bax). In addition, the down regulation of phosphorylated ERK were also found in cells treated with the combination of PPZ and TRAIL.Conclusion The combination of TRAIL and PPZ may be considered as an approach to overcome the resistance of TRAIL in cancer treatment.Citation Format: Sang Young Roh, Jae Ho Byun, Byoungyong Shim, Young Seon Hong. Combination treatment of pantoprazole and TRAIL reduce cell viability by activating caspase cascade and down-regulation of phosphorylated ERK in AGS cell line. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 977. doi:10.1158/1538-7445.AM2013-977" @default.
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- W2020733715 date "2013-04-15" @default.
- W2020733715 modified "2023-09-25" @default.
- W2020733715 title "Abstract 977: Combination treatment of pantoprazole and TRAIL reduce cell viability by activating caspase cascade and down-regulation of phosphorylated ERK in AGS cell line." @default.
- W2020733715 doi "https://doi.org/10.1158/1538-7445.am2013-977" @default.
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