FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2020747992> ?p ?o ?g. }

• W2020747992 endingPage "1132" @default.
• W2020747992 startingPage "1123" @default.
• W2020747992 abstract "The Kinetics of the binding of librium to bovine serum albumin were investigated at an ionic strength of 0.15 M, in the pH-range between 5.5 and 10.5, using the temperature-jump method. Two relaxation times were observed. The first, rapid one is assigned to the equilibrium between reactants and complex, whereas the second, slower relaxation time measures a conformational change of this complex. Both relaxation times are independent of pH up to about 8.0 when they increase sharply to a new plateau at a pH of about 9.3. A possible parallelism between this behavior and the N ⇌ B transition of albumin is discussed. The overall equilibrium constant K, as well as the equilibrium constant between the two conformers, K2, were estimated from our kinetic results. Whereas the change of K with changing pH was within the experimental error, the equilibrium between the two conformers of the complex is somewhat shifted by an increase of the pH. At all values of pH, however, they are present in comparable concentrations. The value of K was also measured spectrophotometrically. The results of the two methods showed reasonable agreement. The relaxation times were affected very little by a change in temperature between 12 and 25°C from which it is concluded that the isomerization has a high negative value of ΔS‡." @default.
• W2020747992 created "2016-06-24" @default.
• W2020747992 creator A5044325212 @default.
• W2020747992 creator A5077557315 @default.
• W2020747992 date "1986-10-01" @default.
• W2020747992 modified "2023-09-26" @default.
• W2020747992 title "Drug-binding to biological macromolecules. A kinetic study of the system chlorodiazepoxide (librium) and bovine serum albumin" @default.
• W2020747992 cites W1518136555 @default.
• W2020747992 cites W1526692287 @default.
• W2020747992 cites W1548016636 @default.
• W2020747992 cites W1566663664 @default.
• W2020747992 cites W1907732933 @default.
• W2020747992 cites W1966843268 @default.
• W2020747992 cites W1977768077 @default.
• W2020747992 cites W1979494628 @default.
• W2020747992 cites W1996937050 @default.
• W2020747992 cites W2005179941 @default.
• W2020747992 cites W2067763408 @default.
• W2020747992 cites W2081479690 @default.
• W2020747992 cites W2093846390 @default.
• W2020747992 cites W2107748559 @default.
• W2020747992 cites W2336599539 @default.
• W2020747992 doi "https://doi.org/10.1002/kin.550181003" @default.
• W2020747992 hasPublicationYear "1986" @default.
• W2020747992 type Work @default.
• W2020747992 sameAs 2020747992 @default.
• W2020747992 citedByCount "3" @default.
• W2020747992 countsByYear W20207479922020 @default.
• W2020747992 countsByYear W20207479922021 @default.
• W2020747992 crossrefType "journal-article" @default.
• W2020747992 hasAuthorship W2020747992A5044325212 @default.
• W2020747992 hasAuthorship W2020747992A5077557315 @default.
• W2020747992 hasConcept C10710636 @default.
• W2020747992 hasConcept C121332964 @default.
• W2020747992 hasConcept C126661725 @default.
• W2020747992 hasConcept C135889238 @default.
• W2020747992 hasConcept C147789679 @default.
• W2020747992 hasConcept C148898269 @default.
• W2020747992 hasConcept C15744967 @default.
• W2020747992 hasConcept C161790260 @default.
• W2020747992 hasConcept C165616093 @default.
• W2020747992 hasConcept C178790620 @default.
• W2020747992 hasConcept C184651966 @default.
• W2020747992 hasConcept C185592680 @default.
• W2020747992 hasConcept C18705241 @default.
• W2020747992 hasConcept C187428577 @default.
• W2020747992 hasConcept C2776029896 @default.
• W2020747992 hasConcept C32909587 @default.
• W2020747992 hasConcept C43617362 @default.
• W2020747992 hasConcept C55493867 @default.
• W2020747992 hasConcept C62520636 @default.
• W2020747992 hasConcept C65550862 @default.
• W2020747992 hasConcept C77805123 @default.
• W2020747992 hasConcept C8010536 @default.
• W2020747992 hasConcept C86807702 @default.
• W2020747992 hasConcept C97355855 @default.
• W2020747992 hasConceptScore W2020747992C10710636 @default.
• W2020747992 hasConceptScore W2020747992C121332964 @default.
• W2020747992 hasConceptScore W2020747992C126661725 @default.
• W2020747992 hasConceptScore W2020747992C135889238 @default.
• W2020747992 hasConceptScore W2020747992C147789679 @default.
• W2020747992 hasConceptScore W2020747992C148898269 @default.
• W2020747992 hasConceptScore W2020747992C15744967 @default.
• W2020747992 hasConceptScore W2020747992C161790260 @default.
• W2020747992 hasConceptScore W2020747992C165616093 @default.
• W2020747992 hasConceptScore W2020747992C178790620 @default.
• W2020747992 hasConceptScore W2020747992C184651966 @default.
• W2020747992 hasConceptScore W2020747992C185592680 @default.
• W2020747992 hasConceptScore W2020747992C18705241 @default.
• W2020747992 hasConceptScore W2020747992C187428577 @default.
• W2020747992 hasConceptScore W2020747992C2776029896 @default.
• W2020747992 hasConceptScore W2020747992C32909587 @default.
• W2020747992 hasConceptScore W2020747992C43617362 @default.
• W2020747992 hasConceptScore W2020747992C55493867 @default.
• W2020747992 hasConceptScore W2020747992C62520636 @default.
• W2020747992 hasConceptScore W2020747992C65550862 @default.
• W2020747992 hasConceptScore W2020747992C77805123 @default.
• W2020747992 hasConceptScore W2020747992C8010536 @default.
• W2020747992 hasConceptScore W2020747992C86807702 @default.
• W2020747992 hasConceptScore W2020747992C97355855 @default.
• W2020747992 hasIssue "10" @default.
• W2020747992 hasLocation W20207479921 @default.
• W2020747992 hasOpenAccess W2020747992 @default.
• W2020747992 hasPrimaryLocation W20207479921 @default.
• W2020747992 hasRelatedWork W1964643455 @default.
• W2020747992 hasRelatedWork W1966520834 @default.
• W2020747992 hasRelatedWork W2000483478 @default.
• W2020747992 hasRelatedWork W2020747992 @default.
• W2020747992 hasRelatedWork W2039102543 @default.
• W2020747992 hasRelatedWork W2070971347 @default.
• W2020747992 hasRelatedWork W2145798098 @default.
• W2020747992 hasRelatedWork W2323190914 @default.
• W2020747992 hasRelatedWork W2362532369 @default.
• W2020747992 hasRelatedWork W2390756360 @default.
• W2020747992 hasVolume "18" @default.
• W2020747992 isParatext "false" @default.
• W2020747992 isRetracted "false" @default.
• W2020747992 magId "2020747992" @default.

• next