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- W2020755315 abstract "The potential threat of parasite resistance to current antimalarials begs further research into antimalarial drug discovery to control disease progression. In addition, even when effective drugs are used, severe malaria symptoms still pose an important risk for death and cerebral residual disease in children. Further understanding of the pathophysiology of malaria and the biology of the parasite will open doors to new antimalarial treatments. Plasmodium falciparum malaria, an infectious disease caused by a parasitic protozoan, claims the lives of nearly a million children each year in Africa alone and is a top public health concern. Evidence is accumulating that resistance to artemisinin derivatives, the frontline therapy for the asexual blood stage of the infection, is developing in southeast Asia. Renewed initiatives to eliminate malaria will benefit from an expanded repertoire of antimalarials, including new drugs that kill circulating P. falciparum gametocytes, thereby preventing transmission. Our current understanding of the biology of asexual blood-stage parasites and gametocytes and the ability to culture them in vitro lends optimism that high-throughput screenings of large chemical libraries will produce a new generation of antimalarial drugs. There is also a need for new therapies to reduce the high mortality of severe malaria. An understanding of the pathophysiology of severe disease may identify rational targets for drugs that improve survival." @default.
- W2020755315 created "2016-06-24" @default.
- W2020755315 creator A5007600048 @default.
- W2020755315 creator A5019122570 @default.
- W2020755315 creator A5056670181 @default.
- W2020755315 creator A5067549205 @default.
- W2020755315 date "2013-02-01" @default.
- W2020755315 modified "2023-10-11" @default.
- W2020755315 title "Malaria biology and disease pathogenesis: insights for new treatments" @default.
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