FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2020761450> ?p ?o ?g. }

• W2020761450 endingPage "345" @default.
• W2020761450 startingPage "337" @default.
• W2020761450 abstract "Agmatine, a divalent diamine with two positive charges at physiological pH, is transported into the matrix of liver mitochondria by an energy-dependent mechanism the driving force of which is ΔΨ (electrical membrane potential). Although this process showed strict electrophoretic behaviour, qualitatively similar to that of polyamines, agmatine is most probably transported by a specific uniporter. Shared transport with polyamines by means of their transporter is excluded, as divalent putrescine and cadaverine are ineffective in inhibiting agmatine uptake. Indeed, the use of the electroneutral transporter of basic amino acids can also be discarded as ornithine, arginine and lysine are completely ineffective at inducing the inhibition of agmatine uptake. The involvement of the monoamine transporter or the existence of a leak pathway are also unlikely. Flux-voltage analysis and the determination of activation enthalpy, which is dependent upon the valence of agmatine, are consistent with the hypothesis that the mitochondrial agmatine transporter is a channel or a single-binding centre-gated pore. The transport of agmatine was non-competitively inhibited by propargylamines, in particular clorgilyne, that are known to be inhibitors of MAO (monoamine oxidase). However, agmatine is normally transported in mitoplasts, thus excluding the involvement of MAO in this process. The I2 imidazoline receptor, which binds agmatine to the mitochondrial membrane, can also be excluded as a possible transporter since its inhibitor, idazoxan, was ineffective at inducing the inhibition of agmatine uptake. Scatchard analysis of membrane binding revealed two types of binding site, S1 and S2, both with mono-co-ordination, and exhibiting high-capacity and low-affinity binding for agmatine compared with polyamines. Agmatine transport in liver mitochondria may be of physiological importance as an indirect regulatory system of cytochrome c oxidase activity and as an inducer mechanism of mitochondrial-mediated apoptosis." @default.
• W2020761450 created "2016-06-24" @default.
• W2020761450 creator A5010020812 @default.
• W2020761450 creator A5022782799 @default.
• W2020761450 creator A5024157908 @default.
• W2020761450 creator A5027182053 @default.
• W2020761450 creator A5036767797 @default.
• W2020761450 creator A5037081874 @default.
• W2020761450 creator A5052248037 @default.
• W2020761450 creator A5067885139 @default.
• W2020761450 creator A5082718909 @default.
• W2020761450 date "2006-05-15" @default.
• W2020761450 modified "2023-10-06" @default.
• W2020761450 title "Agmatine is transported into liver mitochondria by a specific electrophoretic mechanism" @default.
• W2020761450 cites W1206408452 @default.
• W2020761450 cites W1506043065 @default.
• W2020761450 cites W1520872674 @default.
• W2020761450 cites W1533501177 @default.
• W2020761450 cites W1549163149 @default.
• W2020761450 cites W1554680374 @default.
• W2020761450 cites W1562871643 @default.
• W2020761450 cites W1573955016 @default.
• W2020761450 cites W1579610048 @default.
• W2020761450 cites W1834041853 @default.
• W2020761450 cites W1910426389 @default.
• W2020761450 cites W1964455445 @default.
• W2020761450 cites W1964927006 @default.
• W2020761450 cites W1982525105 @default.
• W2020761450 cites W1983335371 @default.
• W2020761450 cites W1984689203 @default.
• W2020761450 cites W1988331824 @default.
• W2020761450 cites W1993717442 @default.
• W2020761450 cites W1995755114 @default.
• W2020761450 cites W2004087403 @default.
• W2020761450 cites W2005991565 @default.
• W2020761450 cites W2008149297 @default.
• W2020761450 cites W2013315842 @default.
• W2020761450 cites W2013389243 @default.
• W2020761450 cites W2013518049 @default.
• W2020761450 cites W2020629542 @default.
• W2020761450 cites W2027751630 @default.
• W2020761450 cites W2030548279 @default.
• W2020761450 cites W2033496106 @default.
• W2020761450 cites W2039629531 @default.
• W2020761450 cites W2043832602 @default.
• W2020761450 cites W2044630163 @default.
• W2020761450 cites W2047499505 @default.
• W2020761450 cites W2052406949 @default.
• W2020761450 cites W2054296575 @default.
• W2020761450 cites W2059928168 @default.
• W2020761450 cites W2067112170 @default.
• W2020761450 cites W2069054116 @default.
• W2020761450 cites W2072756792 @default.
• W2020761450 cites W2073918561 @default.
• W2020761450 cites W2075414867 @default.
• W2020761450 cites W2078324060 @default.
• W2020761450 cites W2086513533 @default.
• W2020761450 cites W2093681309 @default.
• W2020761450 cites W2095558833 @default.
• W2020761450 cites W2098138128 @default.
• W2020761450 cites W2100608778 @default.
• W2020761450 cites W2108398230 @default.
• W2020761450 cites W2110769247 @default.
• W2020761450 cites W2125463704 @default.
• W2020761450 cites W2141258007 @default.
• W2020761450 cites W2159302232 @default.
• W2020761450 cites W2189455942 @default.
• W2020761450 cites W2223031716 @default.
• W2020761450 cites W2240976091 @default.
• W2020761450 doi "https://doi.org/10.1042/bj20060003" @default.
• W2020761450 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1462718" @default.
• W2020761450 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16509824" @default.
• W2020761450 hasPublicationYear "2006" @default.
• W2020761450 type Work @default.
• W2020761450 sameAs 2020761450 @default.
• W2020761450 citedByCount "26" @default.
• W2020761450 countsByYear W20207614502012 @default.
• W2020761450 countsByYear W20207614502013 @default.
• W2020761450 countsByYear W20207614502014 @default.
• W2020761450 countsByYear W20207614502016 @default.
• W2020761450 countsByYear W20207614502017 @default.
• W2020761450 countsByYear W20207614502019 @default.
• W2020761450 countsByYear W20207614502020 @default.
• W2020761450 crossrefType "journal-article" @default.
• W2020761450 hasAuthorship W2020761450A5010020812 @default.
• W2020761450 hasAuthorship W2020761450A5022782799 @default.
• W2020761450 hasAuthorship W2020761450A5024157908 @default.
• W2020761450 hasAuthorship W2020761450A5027182053 @default.
• W2020761450 hasAuthorship W2020761450A5036767797 @default.
• W2020761450 hasAuthorship W2020761450A5037081874 @default.
• W2020761450 hasAuthorship W2020761450A5052248037 @default.
• W2020761450 hasAuthorship W2020761450A5067885139 @default.
• W2020761450 hasAuthorship W2020761450A5082718909 @default.
• W2020761450 hasBestOaLocation W20207614502 @default.
• W2020761450 hasConcept C104317684 @default.
• W2020761450 hasConcept C12554922 @default.
• W2020761450 hasConcept C149011108 @default.
• W2020761450 hasConcept C181199279 @default.

• next