Matches in SemOpenAlex for { <https://semopenalex.org/work/W2020764512> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W2020764512 endingPage "109" @default.
- W2020764512 startingPage "101" @default.
- W2020764512 abstract "Derivatives of Sabin 3 shed from recipients of oral poliovirus vaccine in the United States (U.S.) were examined for genetic changes identified in strains excreted by vaccinees in the United Kingdom [U.K.; Evans et al., 1985; Cammack et al., 1988, Macadam et al., 1989]. Among the eight primary vaccinees studied, the duration of excretion and molecular evolution of type 3 strains varied greatly. The period of virus excretion after vaccination ranged from as few as 2 days to as many as 36 days. Nucleotide sequence analysis of viral RNAs extracted from shed virus indicated that only fifty percent of the vaccinees exclusively excreted strains in which the attenuating mutation at nucleotide 472 in the 5' noncoding region of the genome had reverted from uracil (U) to cytosine (C), the nucleotide found in neurovirulent strains. Compared to the wild-type Leon strain, the low activity of stool isolate KW4 in a complete monkey neurovirulence test demonstrated that presence of C at 472 does not render a type 3 strain pathogenic. Conversely, an isolate was identified which efficiently replicated in monkey nervous tissue and maintained the attenuated U at 472. Oligonucleotide fingerprinting and sequence analysis of viral RNAs from stool isolates indicated that one vaccinee (KW) eventually excreted intertypic recombinant strains consistent with those reported in the U.K. studies. Unique to this study, one vaccinee (KS) excreted nonrecombinant virus possessing U at 472 for up to 21 days. The significance of the KS strain profile in relation to differences in the U.S. vaccine compared to the vaccine distributed in the U.K. and other countries is discussed." @default.
- W2020764512 created "2016-06-24" @default.
- W2020764512 creator A5000719688 @default.
- W2020764512 creator A5005693584 @default.
- W2020764512 creator A5022391999 @default.
- W2020764512 creator A5025806177 @default.
- W2020764512 creator A5027928774 @default.
- W2020764512 creator A5032432011 @default.
- W2020764512 creator A5038735531 @default.
- W2020764512 creator A5038820914 @default.
- W2020764512 creator A5049305233 @default.
- W2020764512 creator A5065853078 @default.
- W2020764512 creator A5069982051 @default.
- W2020764512 date "1991-10-01" @default.
- W2020764512 modified "2023-10-01" @default.
- W2020764512 title "Oral poliovirus vaccine in the United States: Molecular characterization of sabin type 3 after replication in the gut of vaccinees" @default.
- W2020764512 cites W1570828652 @default.
- W2020764512 cites W1853272854 @default.
- W2020764512 cites W1975021289 @default.
- W2020764512 cites W1989848297 @default.
- W2020764512 cites W1993392704 @default.
- W2020764512 cites W2018111000 @default.
- W2020764512 cites W2029618072 @default.
- W2020764512 cites W2030583381 @default.
- W2020764512 cites W2032360710 @default.
- W2020764512 cites W2035273854 @default.
- W2020764512 cites W2044967254 @default.
- W2020764512 cites W2074299714 @default.
- W2020764512 cites W2086657415 @default.
- W2020764512 cites W2104748973 @default.
- W2020764512 cites W2121253082 @default.
- W2020764512 cites W2124934598 @default.
- W2020764512 cites W2132313775 @default.
- W2020764512 cites W2149751835 @default.
- W2020764512 cites W2166195426 @default.
- W2020764512 cites W4292672029 @default.
- W2020764512 doi "https://doi.org/10.1002/jmv.1890350206" @default.
- W2020764512 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1662701" @default.
- W2020764512 hasPublicationYear "1991" @default.
- W2020764512 type Work @default.
- W2020764512 sameAs 2020764512 @default.
- W2020764512 citedByCount "21" @default.
- W2020764512 countsByYear W20207645122013 @default.
- W2020764512 countsByYear W20207645122014 @default.
- W2020764512 countsByYear W20207645122018 @default.
- W2020764512 countsByYear W20207645122023 @default.
- W2020764512 crossrefType "journal-article" @default.
- W2020764512 hasAuthorship W2020764512A5000719688 @default.
- W2020764512 hasAuthorship W2020764512A5005693584 @default.
- W2020764512 hasAuthorship W2020764512A5022391999 @default.
- W2020764512 hasAuthorship W2020764512A5025806177 @default.
- W2020764512 hasAuthorship W2020764512A5027928774 @default.
- W2020764512 hasAuthorship W2020764512A5032432011 @default.
- W2020764512 hasAuthorship W2020764512A5038735531 @default.
- W2020764512 hasAuthorship W2020764512A5038820914 @default.
- W2020764512 hasAuthorship W2020764512A5049305233 @default.
- W2020764512 hasAuthorship W2020764512A5065853078 @default.
- W2020764512 hasAuthorship W2020764512A5069982051 @default.
- W2020764512 hasConcept C159047783 @default.
- W2020764512 hasConcept C22070199 @default.
- W2020764512 hasConcept C2522874641 @default.
- W2020764512 hasConcept C2777888124 @default.
- W2020764512 hasConcept C2779631682 @default.
- W2020764512 hasConcept C86803240 @default.
- W2020764512 hasConceptScore W2020764512C159047783 @default.
- W2020764512 hasConceptScore W2020764512C22070199 @default.
- W2020764512 hasConceptScore W2020764512C2522874641 @default.
- W2020764512 hasConceptScore W2020764512C2777888124 @default.
- W2020764512 hasConceptScore W2020764512C2779631682 @default.
- W2020764512 hasConceptScore W2020764512C86803240 @default.
- W2020764512 hasIssue "2" @default.
- W2020764512 hasLocation W20207645121 @default.
- W2020764512 hasLocation W20207645122 @default.
- W2020764512 hasOpenAccess W2020764512 @default.
- W2020764512 hasPrimaryLocation W20207645121 @default.
- W2020764512 hasRelatedWork W1599532661 @default.
- W2020764512 hasRelatedWork W1653938941 @default.
- W2020764512 hasRelatedWork W1975587515 @default.
- W2020764512 hasRelatedWork W1981373719 @default.
- W2020764512 hasRelatedWork W2006840513 @default.
- W2020764512 hasRelatedWork W2012539582 @default.
- W2020764512 hasRelatedWork W2043553455 @default.
- W2020764512 hasRelatedWork W2064399553 @default.
- W2020764512 hasRelatedWork W2068913867 @default.
- W2020764512 hasRelatedWork W2114281416 @default.
- W2020764512 hasVolume "35" @default.
- W2020764512 isParatext "false" @default.
- W2020764512 isRetracted "false" @default.
- W2020764512 magId "2020764512" @default.
- W2020764512 workType "article" @default.