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• W2020764585 abstract "Abstract Objective Investigators in this study undertook to determine whether in vitro antigen‐responsive immune (polyomavirus T antigen [T‐ag]– specific) and autoimmune (histone‐specific) T cells from normal individuals share structural and genetic characteristics with those from patients with systemic lupus erythematosus (SLE). Methods Histone‐specific T cells were generated by stimulation of peripheral blood mononuclear cells (PBMCs) with nucleosome–T‐ag complexes and were subsequently maintained by pure histones. T‐ag–specific T cell clones were initiated and maintained by T‐ag. The frequencies of circulating histone‐ and T‐ag–specific T cells were determined in healthy individuals and in SLE patients by limiting dilution of PBMCs. T cell receptor (TCR) gene usage and variable‐region structures were determined by complementary DNA sequencing. These sequences were compared between T‐ag– and histone‐specific T cells and between normal individuals and SLE patients for each specificity. Results Individual in vitro–expanded histone‐ and T‐ag–specific T cells from normal individuals displayed identical TCR V α and/or V β chain third complementarity‐determining region (CDR3) sequences, indicating that they were clonally expanded in vivo. The frequencies of in vitro antigen‐responsive T‐ag– or histone‐specific T cells from normal individuals were similar to those from SLE patients. Although heterogeneous for variable‐region structure and gene usage, histone‐specific T cells from healthy individuals and SLE patients selected aspartic and/or glutamic acids at positions 99 and/or 100 of the V β CDR3 sequence. Conclusion Autoimmune T cells from healthy individuals can be activated by nucleosome– T‐ag complexes and maintained by histones in vitro. Such T cells possessed TCR structures similar to those from SLE patients, demonstrating that T cell autoimmunity to nucleosomes may be a latent property of the normal immune system." @default.
• W2020764585 created "2016-06-24" @default.
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• W2020764585 date "2002-05-01" @default.
• W2020764585 modified "2023-10-18" @default.
• W2020764585 title "T cell autoimmunity to histones and nucleosomes is a latent property of the normal immune system" @default.
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• W2020764585 doi "https://doi.org/10.1002/art.10254" @default.
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