FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2020771331> ?p ?o ?g. }

• W2020771331 endingPage "725" @default.
• W2020771331 startingPage "718" @default.
• W2020771331 abstract "Epidemiological evidences suggest that the progression and promotion of prostate cancer (CaP) can be modulated by diet. Since all men die with prostate cancer rather than of the disease, it is of particular interest to prevent or delay the progression of the disease by chemopreventive strategies. We have been studying the anticancer properties of compounds present in cruciferous vegetables such as indole-3-carbinol (I3C). Diindolylmethane (DIM) is a dimer of I3C that is formed under acidic conditions and unlike I3C is more stable with higher anti-cancer effects. In the present report, we demonstrate that DIM is a potent anti-proliferative agent compared to I3C in the hormone independent DU 145 CaP cells. The anti-prostate cancer effect is mediated by the inhibition of the Akt signal transduction pathway as DIM, in sharp contrast to I3C, induces the downregulation of Akt, p-Akt, and PI3 kinase. DIM also induced a G1 arrest in DU 145 cells by flow cytometry and downstream concurrent inhibition of cell cycle parameters such as cyclin D1, cdk4, and cdk6. Our data suggest a need for further development of DIM, as a chemopreventive agent for CaP, which justifies epidemiological evidences and molecular targets that are determinants for CaP dissemination/progression. The ingestion of DIM may benefit CaP patients and reduce disease recurrence by eliminating micro-metastases that may be present in patients who undergo radical prostatectomy." @default.
• W2020771331 created "2016-06-24" @default.
• W2020771331 creator A5006905292 @default.
• W2020771331 creator A5052631174 @default.
• W2020771331 creator A5065511396 @default.
• W2020771331 creator A5085244083 @default.
• W2020771331 creator A5088493178 @default.
• W2020771331 date "2006-02-01" @default.
• W2020771331 modified "2023-10-16" @default.
• W2020771331 title "3,3′-Diindolylmethane downregulates pro-survival pathway in hormone independent prostate cancer" @default.
• W2020771331 cites W1951528568 @default.
• W2020771331 cites W1967275220 @default.
• W2020771331 cites W1978960998 @default.
• W2020771331 cites W1979805598 @default.
• W2020771331 cites W1981926854 @default.
• W2020771331 cites W1984418041 @default.
• W2020771331 cites W1995581888 @default.
• W2020771331 cites W1998394615 @default.
• W2020771331 cites W2006184780 @default.
• W2020771331 cites W2011757623 @default.
• W2020771331 cites W2014906909 @default.
• W2020771331 cites W2025288244 @default.
• W2020771331 cites W2026389696 @default.
• W2020771331 cites W2031626307 @default.
• W2020771331 cites W2032131631 @default.
• W2020771331 cites W2058733098 @default.
• W2020771331 cites W2063344487 @default.
• W2020771331 cites W2066669204 @default.
• W2020771331 cites W2070732456 @default.
• W2020771331 cites W2071458938 @default.
• W2020771331 cites W2071643828 @default.
• W2020771331 cites W2071927813 @default.
• W2020771331 cites W2084284247 @default.
• W2020771331 cites W2085593164 @default.
• W2020771331 cites W2091772367 @default.
• W2020771331 cites W2093821944 @default.
• W2020771331 cites W2094183836 @default.
• W2020771331 cites W2095963384 @default.
• W2020771331 cites W2100837269 @default.
• W2020771331 cites W2103177037 @default.
• W2020771331 cites W2105353478 @default.
• W2020771331 cites W2107476734 @default.
• W2020771331 cites W2114199830 @default.
• W2020771331 cites W2118397996 @default.
• W2020771331 cites W2136217164 @default.
• W2020771331 cites W2138178697 @default.
• W2020771331 cites W2141730376 @default.
• W2020771331 cites W2147266699 @default.
• W2020771331 cites W2148180201 @default.
• W2020771331 cites W2150233389 @default.
• W2020771331 cites W2161810908 @default.
• W2020771331 cites W2163895012 @default.
• W2020771331 cites W2385156238 @default.
• W2020771331 cites W2388163742 @default.
• W2020771331 cites W4293203332 @default.
• W2020771331 doi "https://doi.org/10.1016/j.bbrc.2005.12.059" @default.
• W2020771331 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16380095" @default.
• W2020771331 hasPublicationYear "2006" @default.
• W2020771331 type Work @default.
• W2020771331 sameAs 2020771331 @default.
• W2020771331 citedByCount "61" @default.
• W2020771331 countsByYear W20207713312012 @default.
• W2020771331 countsByYear W20207713312013 @default.
• W2020771331 countsByYear W20207713312014 @default.
• W2020771331 countsByYear W20207713312015 @default.
• W2020771331 countsByYear W20207713312016 @default.
• W2020771331 countsByYear W20207713312017 @default.
• W2020771331 countsByYear W20207713312019 @default.
• W2020771331 countsByYear W20207713312020 @default.
• W2020771331 countsByYear W20207713312021 @default.
• W2020771331 countsByYear W20207713312022 @default.
• W2020771331 crossrefType "journal-article" @default.
• W2020771331 hasAuthorship W2020771331A5006905292 @default.
• W2020771331 hasAuthorship W2020771331A5052631174 @default.
• W2020771331 hasAuthorship W2020771331A5065511396 @default.
• W2020771331 hasAuthorship W2020771331A5085244083 @default.
• W2020771331 hasAuthorship W2020771331A5088493178 @default.
• W2020771331 hasConcept C121608353 @default.
• W2020771331 hasConcept C126322002 @default.
• W2020771331 hasConcept C134018914 @default.
• W2020771331 hasConcept C199649820 @default.
• W2020771331 hasConcept C199835354 @default.
• W2020771331 hasConcept C2776235491 @default.
• W2020771331 hasConcept C2780192828 @default.
• W2020771331 hasConcept C29537977 @default.
• W2020771331 hasConcept C502942594 @default.
• W2020771331 hasConcept C62478195 @default.
• W2020771331 hasConcept C71924100 @default.
• W2020771331 hasConcept C75217442 @default.
• W2020771331 hasConcept C86803240 @default.
• W2020771331 hasConcept C95444343 @default.
• W2020771331 hasConceptScore W2020771331C121608353 @default.
• W2020771331 hasConceptScore W2020771331C126322002 @default.
• W2020771331 hasConceptScore W2020771331C134018914 @default.
• W2020771331 hasConceptScore W2020771331C199649820 @default.
• W2020771331 hasConceptScore W2020771331C199835354 @default.
• W2020771331 hasConceptScore W2020771331C2776235491 @default.
• W2020771331 hasConceptScore W2020771331C2780192828 @default.

• next