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- W2020777745 abstract "Intravenous injection of therapeutics is required to effectively treat or cure metastatic cancer, certain cardiovascular diseases, and other acquired or inherited diseases. Using this route of delivery allows potential uptake in all disease targets that are accessed by the bloodstream. However, normal tissues and organs also have the potential for uptake of therapeutic agents. Therefore, investigators have used targeted delivery to attempt delivery solely to the target cells; however, use of ligands on the surface of delivery vehicles to target specific cell surface receptors is not sufficient to avoid nonspecific uptake. PEGylation has been used for decades to try to avoid nonspecific uptake but suffers from many problems known as The PEGylation Dilemma. We have solved this dilemma by replacing PEGylation with reversible masking using low-molecular-weight neutral lipids in order to achieve optimal-targeted delivery solely to target cells. Our paper will focus on this topic." @default.
- W2020777745 created "2016-06-24" @default.
- W2020777745 creator A5046995957 @default.
- W2020777745 creator A5068870333 @default.
- W2020777745 date "2012-05-10" @default.
- W2020777745 modified "2023-10-14" @default.
- W2020777745 title "Reversible Masking Using Low-Molecular-Weight Neutral Lipids to Achieve Optimal-Targeted Delivery" @default.
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- W2020777745 doi "https://doi.org/10.1155/2012/173465" @default.
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