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• W2020787369 endingPage "29" @default.
• W2020787369 startingPage "22" @default.
• W2020787369 abstract "Retrospective study of 23 patients treated with conformal radiotherapy for a locally advanced bile duct carcinoma.Eight cases were irradiated after a radical resection (R0), because they were N+; seven after microscopically incomplete resection (R1); seven were not resected (R2). A dose of 45 of 50 Gy was delivered, followed by a boost up to 60 Gy in R1 and R2 groups. Concomitant chemotherapy was given in 15 cases.Late toxicity included a stenosis of the duodenum, and one of the biliary anastomosis. Two patients died from cholangitis, the mechanism of which remains unclear. Five patients are in complete remission, six had a local relapse, four developed a peritoneal carcinosis, and six distant metastases. Actuarial survival rate is 75%, 28% and 7% at 1, 3 and 5 years, respectively (median: 16.5 months). Seven patients are still alive with a 4 to 70 months follow-up. Survival is similar in the 3 small subgroups. The poor local control among R0N+ cases might be related to the absence of a boost to the tumor bed. In R1 patients, relapses were mainly distant metastases, whereas local and peritoneal recurrences predominated in R2.Conformal radiochemotherapy delivering 60 Gy represents a valuable palliative approach in locally advanced biliary carcinoma." @default.
• W2020787369 created "2016-06-24" @default.
• W2020787369 creator A5002972654 @default.
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• W2020787369 date "2002-02-01" @default.
• W2020787369 modified "2023-09-27" @default.
• W2020787369 title "Radiothérapie conformationnelle des cholangiocarcinomes de la voie biliaire principale localement évolués" @default.
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• W2020787369 doi "https://doi.org/10.1016/s1278-3218(01)00144-5" @default.
• W2020787369 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11899677" @default.

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