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- W2020787569 abstract "Abstract Proteomics is rapidly transforming the way that cancer and other pathologies are investigated. The ability to identify hundreds of proteins and to compare their abundance in different clinical samples presents a unique opportunity for direct identification of novel disease markers. Furthermore, recent advances allow us to analyse and compare PTMs. This gives an additional dimension for defining a new class of protein biomarker based not only on abundance and expression but also on the occurrence of covalent modifications specific to a disease state or therapy response. Such modifications are often a consequence of the activation/inactivation of a particular disease related pathway. In this review we evaluate the available information on breast cancer related protein‐phosphorylation events, illustrating the rationale for investigating this PTM as a target for breast cancer research with eventual clinical relevance. We present a critical survey of the published experimental strategies to study protein phosphorylation on a system wide scale and highlight recent specific advances in breast cancer phosphoproteomics. Finally we discuss the feasibility of establishing novel biomarkers for breast cancer based on the detection of patterns of specific protein phosphorylation events." @default.
- W2020787569 created "2016-06-24" @default.
- W2020787569 creator A5015576945 @default.
- W2020787569 creator A5045757553 @default.
- W2020787569 date "2008-02-01" @default.
- W2020787569 modified "2023-09-25" @default.
- W2020787569 title "Phosphoproteomics: A possible route to novel biomarkers of breast cancer" @default.
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