FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2020800447> ?p ?o ?g. }

• W2020800447 endingPage "137" @default.
• W2020800447 startingPage "131" @default.
• W2020800447 abstract "Excitatory amino acids (EAA), mainly glutamate and aspartate, are released in excessive amounts from terminals of ischemic or traumatically injured neurons. These excessive levels of EAAs initiate a cascade of events believed to lead to secondary delayed damage to the surrounding brain. The N-methyl-D-aspartate receptor antagonists MK-801 and ketamine are reported to suppress excessive EAA release and to attenuate the development of focal brain edema following neuronal injury. Magnesium is also reported to work at the postsynaptic receptor to reduce the neurotoxic effect of glutamate. The present study was undertaken to examine the effect of postinjury treatment with Mg++ on brain edema and neurological outcome after traumatic brain injury. Sixty-nine rats that survived halothane anesthesia and closed head trauma (CHT) were randomly assigned to one of seven experimental groups: sham, CHT, and CHT with administration of Mg++ 1 hour postinjury. At 48 hours, brain tissue Mg++ concentration (calculated from optical density using a standard curve) was significantly increased compared to baseline levels (10.06 +/- 2.44 mg/g vs. 6.83 +/- 0.81 mg/g, p < 0.01 calculated by one-way analysis of variance). Also at 48 hours postinjury, brain tissue specific gravity in the contused hemisphere of Mg(++)-treated rats was significantly greater than that in the contused hemisphere of untreated rats, indicating attenuation of brain edema formation by Mg++. The neurological severity score (NSS) of rats treated with Mg++ improved significantly at both 18 and 48 hours, compared to baseline values obtained 1 hour after CHT but prior to administration of Mg++ (11.2 +/- 2.5 vs. 15.2 +/- 4.1, p = 0.03; and 12.3 +/- 6.1 vs. 17.3 +/- 3.6, p = 0.004, respectively). In the untreated groups, the NSS at 18 and 48 hours was not significantly different from baseline values (that is, no neurological improvement). The present study indicates that postinjury treatment with Mg++ attenuates brain edema formation and improves neurological outcome after experimental CHT." @default.
• W2020800447 created "2016-06-24" @default.
• W2020800447 creator A5012567172 @default.
• W2020800447 creator A5016644943 @default.
• W2020800447 creator A5017249320 @default.
• W2020800447 creator A5020823107 @default.
• W2020800447 creator A5030281337 @default.
• W2020800447 creator A5080566914 @default.
• W2020800447 creator A5083331252 @default.
• W2020800447 date "1996-07-01" @default.
• W2020800447 modified "2023-09-26" @default.
• W2020800447 title "Effect of magnesium given 1 hour after head trauma on brain edema and neurological outcome" @default.
• W2020800447 cites W1481750217 @default.
• W2020800447 cites W1594476703 @default.
• W2020800447 cites W1891815016 @default.
• W2020800447 cites W1910864442 @default.
• W2020800447 cites W1957958801 @default.
• W2020800447 cites W1972460915 @default.
• W2020800447 cites W1974879850 @default.
• W2020800447 cites W1975374033 @default.
• W2020800447 cites W1977929251 @default.
• W2020800447 cites W1979406476 @default.
• W2020800447 cites W1989910382 @default.
• W2020800447 cites W1990948475 @default.
• W2020800447 cites W1991178310 @default.
• W2020800447 cites W1992026104 @default.
• W2020800447 cites W1992681847 @default.
• W2020800447 cites W1993893408 @default.
• W2020800447 cites W1995812083 @default.
• W2020800447 cites W1997568797 @default.
• W2020800447 cites W1998347917 @default.
• W2020800447 cites W2000060567 @default.
• W2020800447 cites W2000655734 @default.
• W2020800447 cites W2002848242 @default.
• W2020800447 cites W2004425757 @default.
• W2020800447 cites W2006100240 @default.
• W2020800447 cites W2006626906 @default.
• W2020800447 cites W2009430022 @default.
• W2020800447 cites W2011092442 @default.
• W2020800447 cites W2016588544 @default.
• W2020800447 cites W2017132655 @default.
• W2020800447 cites W2022068824 @default.
• W2020800447 cites W2028758897 @default.
• W2020800447 cites W2031625366 @default.
• W2020800447 cites W2033935316 @default.
• W2020800447 cites W2034805261 @default.
• W2020800447 cites W2035254789 @default.
• W2020800447 cites W2035609099 @default.
• W2020800447 cites W2041081004 @default.
• W2020800447 cites W2041125071 @default.
• W2020800447 cites W2042200838 @default.
• W2020800447 cites W2042271778 @default.
• W2020800447 cites W2042550512 @default.
• W2020800447 cites W2047982771 @default.
• W2020800447 cites W2049158024 @default.
• W2020800447 cites W2051395367 @default.
• W2020800447 cites W2052503599 @default.
• W2020800447 cites W2056541767 @default.
• W2020800447 cites W2056811790 @default.
• W2020800447 cites W2061048878 @default.
• W2020800447 cites W2072918771 @default.
• W2020800447 cites W2073883806 @default.
• W2020800447 cites W2085203291 @default.
• W2020800447 cites W2086951942 @default.
• W2020800447 cites W2087322478 @default.
• W2020800447 cites W2087916050 @default.
• W2020800447 cites W2116188145 @default.
• W2020800447 cites W2131785813 @default.
• W2020800447 cites W2132197484 @default.
• W2020800447 cites W2334270473 @default.
• W2020800447 cites W2335692897 @default.
• W2020800447 cites W2469974450 @default.
• W2020800447 cites W4213026818 @default.
• W2020800447 cites W4256446632 @default.
• W2020800447 doi "https://doi.org/10.3171/jns.1996.85.1.0131" @default.
• W2020800447 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8683262" @default.
• W2020800447 hasPublicationYear "1996" @default.
• W2020800447 type Work @default.
• W2020800447 sameAs 2020800447 @default.
• W2020800447 citedByCount "118" @default.
• W2020800447 countsByYear W20208004472012 @default.
• W2020800447 countsByYear W20208004472013 @default.
• W2020800447 countsByYear W20208004472014 @default.
• W2020800447 countsByYear W20208004472015 @default.
• W2020800447 countsByYear W20208004472016 @default.
• W2020800447 countsByYear W20208004472017 @default.
• W2020800447 countsByYear W20208004472018 @default.
• W2020800447 countsByYear W20208004472019 @default.
• W2020800447 countsByYear W20208004472020 @default.
• W2020800447 crossrefType "journal-article" @default.
• W2020800447 hasAuthorship W2020800447A5012567172 @default.
• W2020800447 hasAuthorship W2020800447A5016644943 @default.
• W2020800447 hasAuthorship W2020800447A5017249320 @default.
• W2020800447 hasAuthorship W2020800447A5020823107 @default.
• W2020800447 hasAuthorship W2020800447A5030281337 @default.
• W2020800447 hasAuthorship W2020800447A5080566914 @default.
• W2020800447 hasAuthorship W2020800447A5083331252 @default.
• W2020800447 hasConcept C118552586 @default.

• next