Matches in SemOpenAlex for { <https://semopenalex.org/work/W2020808567> ?p ?o ?g. }
- W2020808567 endingPage "42" @default.
- W2020808567 startingPage "37" @default.
- W2020808567 abstract "Chorioamnionitis is one of the important causes of preterm labor. Preterm labor with chorioamnionitis is associated with oxidative stress. We reported that 4-hydroxy-2-nonenal (4-HNE), a major end product of oxidative fatty acid metabolism, is accumulated in the placenta with chorioamnionitis. The aim of this study was to confirm the effect of 4-HNE on cyclooxygenase-2 (COX-2) and prostaglandin (PG) induction in the uterine myometrial tissues. We also examined the effect of N-acetylcysteine (NAC) on 4-HNE-induced COX-2 expression.Uterine myometrial tissues were obtained from 5 patients. One of them underwent elective cesarean section without labor, and 4 of them underwent hysterectomy because of placental previa or atonic bleeding. We stimulated the uterine myometrial tissues with 4-HNE. In addition, the tissues were pretreated with NAC before 4-HNE treatment. The expression of COX-2 mRNA was observed by real-time PCR. PGE2 and prostacyclin release into the supernatants of the tissue cultures was measured by ELISA.4-HNE induced the COX-2 mRNA expression and PGE2 production in the uterine myometrial tissue culture in a dose-dependent and time-dependent manner. NAC inhibited 4-HNE-induced COX-2 expression.4-HNE may play an important role in preterm labor. NAC might be protective against preterm labor under oxidative stress." @default.
- W2020808567 created "2016-06-24" @default.
- W2020808567 creator A5023616806 @default.
- W2020808567 creator A5039386041 @default.
- W2020808567 creator A5042920663 @default.
- W2020808567 creator A5043855337 @default.
- W2020808567 creator A5055405608 @default.
- W2020808567 creator A5058637700 @default.
- W2020808567 creator A5066593729 @default.
- W2020808567 creator A5071254876 @default.
- W2020808567 creator A5078213723 @default.
- W2020808567 creator A5081618473 @default.
- W2020808567 date "2011-01-01" @default.
- W2020808567 modified "2023-10-14" @default.
- W2020808567 title "Effects of 4-Hydroxy-2-Nonenal, a Major Lipid Peroxidation-Derived Aldehyde, and N-Acetylcysteine on the Cyclooxygenase-2 Expression in Human Uterine Myometrium" @default.
- W2020808567 cites W1579450354 @default.
- W2020808567 cites W180197682 @default.
- W2020808567 cites W1844075866 @default.
- W2020808567 cites W1964106290 @default.
- W2020808567 cites W1970016508 @default.
- W2020808567 cites W1972457815 @default.
- W2020808567 cites W1985088376 @default.
- W2020808567 cites W1991262780 @default.
- W2020808567 cites W1997727568 @default.
- W2020808567 cites W2008574812 @default.
- W2020808567 cites W2016659985 @default.
- W2020808567 cites W2022431707 @default.
- W2020808567 cites W2024179737 @default.
- W2020808567 cites W2026657665 @default.
- W2020808567 cites W2027457818 @default.
- W2020808567 cites W2033588134 @default.
- W2020808567 cites W2039286176 @default.
- W2020808567 cites W2040919051 @default.
- W2020808567 cites W2041473084 @default.
- W2020808567 cites W2045642603 @default.
- W2020808567 cites W2057522312 @default.
- W2020808567 cites W2074075170 @default.
- W2020808567 cites W2076689859 @default.
- W2020808567 cites W2079527302 @default.
- W2020808567 cites W2080326524 @default.
- W2020808567 cites W2084646646 @default.
- W2020808567 cites W2087638046 @default.
- W2020808567 cites W2120714648 @default.
- W2020808567 cites W2129159625 @default.
- W2020808567 cites W2135757251 @default.
- W2020808567 cites W2157176207 @default.
- W2020808567 cites W2165751124 @default.
- W2020808567 cites W2165991783 @default.
- W2020808567 cites W2171224841 @default.
- W2020808567 cites W4243140277 @default.
- W2020808567 doi "https://doi.org/10.1159/000322393" @default.
- W2020808567 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21212636" @default.
- W2020808567 hasPublicationYear "2011" @default.
- W2020808567 type Work @default.
- W2020808567 sameAs 2020808567 @default.
- W2020808567 citedByCount "5" @default.
- W2020808567 countsByYear W20208085672012 @default.
- W2020808567 countsByYear W20208085672013 @default.
- W2020808567 countsByYear W20208085672015 @default.
- W2020808567 countsByYear W20208085672019 @default.
- W2020808567 crossrefType "journal-article" @default.
- W2020808567 hasAuthorship W2020808567A5023616806 @default.
- W2020808567 hasAuthorship W2020808567A5039386041 @default.
- W2020808567 hasAuthorship W2020808567A5042920663 @default.
- W2020808567 hasAuthorship W2020808567A5043855337 @default.
- W2020808567 hasAuthorship W2020808567A5055405608 @default.
- W2020808567 hasAuthorship W2020808567A5058637700 @default.
- W2020808567 hasAuthorship W2020808567A5066593729 @default.
- W2020808567 hasAuthorship W2020808567A5071254876 @default.
- W2020808567 hasAuthorship W2020808567A5078213723 @default.
- W2020808567 hasAuthorship W2020808567A5081618473 @default.
- W2020808567 hasConcept C126322002 @default.
- W2020808567 hasConcept C134018914 @default.
- W2020808567 hasConcept C16685009 @default.
- W2020808567 hasConcept C172680121 @default.
- W2020808567 hasConcept C181199279 @default.
- W2020808567 hasConcept C185592680 @default.
- W2020808567 hasConcept C2776151105 @default.
- W2020808567 hasConcept C2777629866 @default.
- W2020808567 hasConcept C2777956040 @default.
- W2020808567 hasConcept C2778164554 @default.
- W2020808567 hasConcept C2779066055 @default.
- W2020808567 hasConcept C2779234561 @default.
- W2020808567 hasConcept C2779689624 @default.
- W2020808567 hasConcept C2780664492 @default.
- W2020808567 hasConcept C2780829032 @default.
- W2020808567 hasConcept C54355233 @default.
- W2020808567 hasConcept C55493867 @default.
- W2020808567 hasConcept C71924100 @default.
- W2020808567 hasConcept C86803240 @default.
- W2020808567 hasConceptScore W2020808567C126322002 @default.
- W2020808567 hasConceptScore W2020808567C134018914 @default.
- W2020808567 hasConceptScore W2020808567C16685009 @default.
- W2020808567 hasConceptScore W2020808567C172680121 @default.
- W2020808567 hasConceptScore W2020808567C181199279 @default.
- W2020808567 hasConceptScore W2020808567C185592680 @default.
- W2020808567 hasConceptScore W2020808567C2776151105 @default.
- W2020808567 hasConceptScore W2020808567C2777629866 @default.