FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2020823922> ?p ?o ?g. }

• W2020823922 endingPage "e30453" @default.
• W2020823922 startingPage "e30453" @default.
• W2020823922 abstract "Fusion of placental villous cytotrophoblasts with the overlying syncytiotrophoblast is essential for the maintenance of successful pregnancy, and disturbances in this process have been implicated in pathological conditions such as pre-eclampsia and intra-uterine growth retardation. In this study we examined the role of the Rho GTPase family member RhoE in trophoblast differentiation and fusion using the BeWo choriocarcinoma cell line, a model of villous cytotrophoblast fusion. Treatment of BeWo cells with the cell permeable cyclic AMP analogue dibutyryl cyclic AMP (dbcAMP) resulted in a strong upregulation of RhoE at 24h, coinciding with the onset of fusion. Using the protein kinase A (PKA)-specific cAMP analogue N6-phenyl-cAMP, and a specific inhibitor of PKA (14–22 amide, PKI), we found that upregulation of RhoE by cAMP was mediated through activation of PKA signalling. Silencing of RhoE expression by RNA interference resulted in a significant decrease in dbcAMP-induced fusion. However, expression of differentiation markers human chorionic gonadotrophin and placental alkaline phosphatase was unaffected by RhoE silencing. Finally, we found that RhoE upregulation by dbcAMP was significantly reduced under hypoxic conditions in which cell fusion is impaired. These results show that induction of RhoE by cAMP is mediated through PKA and promotes BeWo cell fusion but has no effect on functional differentiation, supporting evidence that these two processes may be controlled by separate or diverging pathways." @default.
• W2020823922 created "2016-06-24" @default.
• W2020823922 creator A5014739696 @default.
• W2020823922 creator A5019167533 @default.
• W2020823922 creator A5066443529 @default.
• W2020823922 creator A5070429427 @default.
• W2020823922 creator A5078577158 @default.
• W2020823922 date "2012-01-17" @default.
• W2020823922 modified "2023-10-15" @default.
• W2020823922 title "RhoE Is Regulated by Cyclic AMP and Promotes Fusion of Human BeWo Choriocarcinoma Cells" @default.
• W2020823922 cites W1558885122 @default.
• W2020823922 cites W1963765620 @default.
• W2020823922 cites W1967565754 @default.
• W2020823922 cites W1972871738 @default.
• W2020823922 cites W1973074263 @default.
• W2020823922 cites W1976091400 @default.
• W2020823922 cites W1981978241 @default.
• W2020823922 cites W1984795213 @default.
• W2020823922 cites W1997380277 @default.
• W2020823922 cites W1998393441 @default.
• W2020823922 cites W2011544204 @default.
• W2020823922 cites W2014707352 @default.
• W2020823922 cites W2023918126 @default.
• W2020823922 cites W2030077396 @default.
• W2020823922 cites W2032867057 @default.
• W2020823922 cites W2035304127 @default.
• W2020823922 cites W2036035596 @default.
• W2020823922 cites W2046124539 @default.
• W2020823922 cites W2050321932 @default.
• W2020823922 cites W2055545486 @default.
• W2020823922 cites W2057113803 @default.
• W2020823922 cites W2058456747 @default.
• W2020823922 cites W2058875973 @default.
• W2020823922 cites W2063575573 @default.
• W2020823922 cites W2063801621 @default.
• W2020823922 cites W2064544429 @default.
• W2020823922 cites W2075624072 @default.
• W2020823922 cites W2081577607 @default.
• W2020823922 cites W2081691778 @default.
• W2020823922 cites W2085503695 @default.
• W2020823922 cites W2091122219 @default.
• W2020823922 cites W2094043939 @default.
• W2020823922 cites W2094395752 @default.
• W2020823922 cites W2102415181 @default.
• W2020823922 cites W2106365461 @default.
• W2020823922 cites W2112203237 @default.
• W2020823922 cites W2123419299 @default.
• W2020823922 cites W2128084689 @default.
• W2020823922 cites W2128496379 @default.
• W2020823922 cites W2131164826 @default.
• W2020823922 cites W2148630798 @default.
• W2020823922 cites W2154180645 @default.
• W2020823922 cites W2160438670 @default.
• W2020823922 cites W2163839814 @default.
• W2020823922 cites W2167503858 @default.
• W2020823922 cites W2168640599 @default.
• W2020823922 cites W2169302665 @default.
• W2020823922 cites W2170239652 @default.
• W2020823922 doi "https://doi.org/10.1371/journal.pone.0030453" @default.
• W2020823922 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3260294" @default.
• W2020823922 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22272352" @default.
• W2020823922 hasPublicationYear "2012" @default.
• W2020823922 type Work @default.
• W2020823922 sameAs 2020823922 @default.
• W2020823922 citedByCount "22" @default.
• W2020823922 countsByYear W20208239222012 @default.
• W2020823922 countsByYear W20208239222013 @default.
• W2020823922 countsByYear W20208239222014 @default.
• W2020823922 countsByYear W20208239222015 @default.
• W2020823922 countsByYear W20208239222016 @default.
• W2020823922 countsByYear W20208239222017 @default.
• W2020823922 countsByYear W20208239222018 @default.
• W2020823922 countsByYear W20208239222019 @default.
• W2020823922 countsByYear W20208239222020 @default.
• W2020823922 countsByYear W20208239222021 @default.
• W2020823922 countsByYear W20208239222022 @default.
• W2020823922 countsByYear W20208239222023 @default.
• W2020823922 crossrefType "journal-article" @default.
• W2020823922 hasAuthorship W2020823922A5014739696 @default.
• W2020823922 hasAuthorship W2020823922A5019167533 @default.
• W2020823922 hasAuthorship W2020823922A5066443529 @default.
• W2020823922 hasAuthorship W2020823922A5070429427 @default.
• W2020823922 hasAuthorship W2020823922A5078577158 @default.
• W2020823922 hasBestOaLocation W20208239221 @default.
• W2020823922 hasConcept C104317684 @default.
• W2020823922 hasConcept C119056186 @default.
• W2020823922 hasConcept C126322002 @default.
• W2020823922 hasConcept C127561419 @default.
• W2020823922 hasConcept C134018914 @default.
• W2020823922 hasConcept C148738053 @default.
• W2020823922 hasConcept C1491633281 @default.
• W2020823922 hasConcept C172680121 @default.
• W2020823922 hasConcept C2776953305 @default.
• W2020823922 hasConcept C2777495146 @default.
• W2020823922 hasConcept C2777605040 @default.
• W2020823922 hasConcept C2779234561 @default.
• W2020823922 hasConcept C2779315647 @default.
• W2020823922 hasConcept C40479148 @default.

• next