FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2020826102> ?p ?o ?g. }

• W2020826102 endingPage "16" @default.
• W2020826102 startingPage "11" @default.
• W2020826102 abstract "The HIV replication cycle passes through a stage of integrating proviral DNA into the cell's DNA. In this process, the viral enzyme, integrase, catalyses two reactions. The first reaction, which seems to occur in the cytoplasm, involves 3'-end processing, in which two nucleotides are removed from the 3' ends of the viral DNA by integrase. The second reaction, which occurs in the nucleus, involves the strand transfer reaction, catalyzed by integrase, in which the recessed 3' ends of the viral DNA are joined to the protruding 5' ends in the target DNA. Although this activity has not yet been completely defined and the structure of the active form of integrase, probably a tetramer, has not been resolved, drugs of the diketoacid (DKA) family have been found. These drugs are highly potent inhibitors of the second phase, the strand transfer reaction. Through a series of optimizations, a highly effective molecule for clinical use, raltegravir, has been achieved. The present article provides a summary of basic knowledge on integrase, as well as the activity and the modes of inhibition of this enzyme. Also discussed is the reduced, but nevertheless real, development of resistance to raltegravir, requiring second-generation integrase inhibitors to be designed." @default.
• W2020826102 created "2016-06-24" @default.
• W2020826102 creator A5016378732 @default.
• W2020826102 date "2008-11-01" @default.
• W2020826102 modified "2023-09-26" @default.
• W2020826102 title "Cómo se integra el ADN proviral en el ADN de la célula del huésped y cómo se puede inhibir el proceso" @default.
• W2020826102 cites W1488580265 @default.
• W2020826102 cites W1536785903 @default.
• W2020826102 cites W180725227 @default.
• W2020826102 cites W1973322678 @default.
• W2020826102 cites W1980869599 @default.
• W2020826102 cites W1984933368 @default.
• W2020826102 cites W1985981188 @default.
• W2020826102 cites W1994195473 @default.
• W2020826102 cites W1994293556 @default.
• W2020826102 cites W1995297340 @default.
• W2020826102 cites W2003425131 @default.
• W2020826102 cites W2005663970 @default.
• W2020826102 cites W2012872136 @default.
• W2020826102 cites W2025444624 @default.
• W2020826102 cites W2025972928 @default.
• W2020826102 cites W2039104683 @default.
• W2020826102 cites W2050310420 @default.
• W2020826102 cites W2054996337 @default.
• W2020826102 cites W2056182928 @default.
• W2020826102 cites W2060369798 @default.
• W2020826102 cites W2063413156 @default.
• W2020826102 cites W2081237483 @default.
• W2020826102 cites W2087400133 @default.
• W2020826102 cites W2088424911 @default.
• W2020826102 cites W2089660336 @default.
• W2020826102 cites W2096768845 @default.
• W2020826102 cites W2107775218 @default.
• W2020826102 cites W2109296787 @default.
• W2020826102 cites W2122691473 @default.
• W2020826102 cites W2123317697 @default.
• W2020826102 cites W2123529547 @default.
• W2020826102 cites W2128944251 @default.
• W2020826102 cites W2136996190 @default.
• W2020826102 cites W2137646827 @default.
• W2020826102 cites W2148026374 @default.
• W2020826102 cites W2148690651 @default.
• W2020826102 cites W2151389386 @default.
• W2020826102 cites W2154190260 @default.
• W2020826102 cites W2157457515 @default.
• W2020826102 cites W2168539374 @default.
• W2020826102 cites W2171711893 @default.
• W2020826102 cites W2171813035 @default.
• W2020826102 cites W2172017348 @default.
• W2020826102 cites W2187415226 @default.
• W2020826102 doi "https://doi.org/10.1016/s0213-005x(08)76567-4" @default.
• W2020826102 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19572420" @default.
• W2020826102 hasPublicationYear "2008" @default.
• W2020826102 type Work @default.
• W2020826102 sameAs 2020826102 @default.
• W2020826102 citedByCount "0" @default.
• W2020826102 crossrefType "journal-article" @default.
• W2020826102 hasAuthorship W2020826102A5016378732 @default.
• W2020826102 hasConcept C104317684 @default.
• W2020826102 hasConcept C142462285 @default.
• W2020826102 hasConcept C14430832 @default.
• W2020826102 hasConcept C153911025 @default.
• W2020826102 hasConcept C159047783 @default.
• W2020826102 hasConcept C181199279 @default.
• W2020826102 hasConcept C185592680 @default.
• W2020826102 hasConcept C2522874641 @default.
• W2020826102 hasConcept C2777302000 @default.
• W2020826102 hasConcept C2778886173 @default.
• W2020826102 hasConcept C2780404665 @default.
• W2020826102 hasConcept C2993143319 @default.
• W2020826102 hasConcept C512185932 @default.
• W2020826102 hasConcept C552990157 @default.
• W2020826102 hasConcept C55493867 @default.
• W2020826102 hasConcept C71240020 @default.
• W2020826102 hasConcept C86803240 @default.
• W2020826102 hasConceptScore W2020826102C104317684 @default.
• W2020826102 hasConceptScore W2020826102C142462285 @default.
• W2020826102 hasConceptScore W2020826102C14430832 @default.
• W2020826102 hasConceptScore W2020826102C153911025 @default.
• W2020826102 hasConceptScore W2020826102C159047783 @default.
• W2020826102 hasConceptScore W2020826102C181199279 @default.
• W2020826102 hasConceptScore W2020826102C185592680 @default.
• W2020826102 hasConceptScore W2020826102C2522874641 @default.
• W2020826102 hasConceptScore W2020826102C2777302000 @default.
• W2020826102 hasConceptScore W2020826102C2778886173 @default.
• W2020826102 hasConceptScore W2020826102C2780404665 @default.
• W2020826102 hasConceptScore W2020826102C2993143319 @default.
• W2020826102 hasConceptScore W2020826102C512185932 @default.
• W2020826102 hasConceptScore W2020826102C552990157 @default.
• W2020826102 hasConceptScore W2020826102C55493867 @default.
• W2020826102 hasConceptScore W2020826102C71240020 @default.
• W2020826102 hasConceptScore W2020826102C86803240 @default.
• W2020826102 hasLocation W20208261021 @default.
• W2020826102 hasLocation W20208261022 @default.
• W2020826102 hasOpenAccess W2020826102 @default.
• W2020826102 hasPrimaryLocation W20208261021 @default.
• W2020826102 hasRelatedWork W1577344326 @default.
• W2020826102 hasRelatedWork W1857359214 @default.

• next