FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2020833122> ?p ?o ?g. }

• W2020833122 endingPage "181" @default.
• W2020833122 startingPage "170" @default.
• W2020833122 abstract "Oxaliplatin (OXAL) is a platinum-based drug used for the treatment of colorectal, lung, breast and ovarian cancers. OXAL does not cause renal or hematologic toxicity. However, OXAL induces neuropathic pain which hampers the chemotherapy success. Attempts with neuroprotective agents including anticonvulsivants and antidepressants were made to prevent OXAL-induced painful neuropathy but the clinical data are controversial and the tested neuroprotectors are able to evoke themselves undesirable effects. Here, we demonstrated that the natural neurosteroid allopregnanolone (3α,5α-THP), known to be devoid of toxic side-effects in humans and experimental models, prevented and suppressed OXAL-induced painful neuropathic symptoms. Indeed, 3α,5α-THP repaired OXAL-evoked neurochemical and functional alterations in peripheral nerves and intra-epidermal nerve fibers (IENF). Behavioral analyses showed that prophylactic or corrective 3α,5α-THP treatment (4 mg/kg/2 days) respectively prevented or abolished OXAL-induced cold allodynia, mechanical allodynia and hyperalgesia by reversing to normal decreased thermal and mechanical pain thresholds of OXAL-treated rats. Electrophysiological investigations revealed that 3α,5α-THP restored control values of sciatic nerve conduction velocity and action potential peak amplitude drastically reduced by OXAL-treatment. Furthermore, immunohistochemistry and confocal microscopic quantifications demonstrated that 3α,5α-THP repaired OXAL-induced neurochemical/cellular alterations by restoring IENF control density and normal level of neurofilament 200 kDa that was strongly repressed by OXAL in dorsal root ganglion neurons and sciatic nerve axons. OXAL showed no toxicity for the non-compact myelin protein 2′,3′-cyclic-nucleotide-3′-phosphodiesterase whose expression level was similarly increased by 3α,5α-THP in controls and OXAL-treated rat nerves. Together, these results may be interesting for the development of natural or safe neurosteroid-based neuroprotective strategy against anticancer drug-evoked painful neuropathy." @default.
• W2020833122 created "2016-06-24" @default.
• W2020833122 creator A5008371415 @default.
• W2020833122 creator A5023780227 @default.
• W2020833122 creator A5078364964 @default.
• W2020833122 creator A5086400517 @default.
• W2020833122 date "2011-01-01" @default.
• W2020833122 modified "2023-10-18" @default.
• W2020833122 title "Allopregnanolone prevents and suppresses oxaliplatin-evoked painful neuropathy: Multi-parametric assessment and direct evidence" @default.
• W2020833122 cites W1526407692 @default.
• W2020833122 cites W1603046163 @default.
• W2020833122 cites W1854588946 @default.
• W2020833122 cites W1964520432 @default.
• W2020833122 cites W1967998583 @default.
• W2020833122 cites W1969414426 @default.
• W2020833122 cites W1971045589 @default.
• W2020833122 cites W1973587788 @default.
• W2020833122 cites W1975943627 @default.
• W2020833122 cites W1981463183 @default.
• W2020833122 cites W1981810830 @default.
• W2020833122 cites W1985109518 @default.
• W2020833122 cites W1987552731 @default.
• W2020833122 cites W1992879638 @default.
• W2020833122 cites W1996800910 @default.
• W2020833122 cites W1997932302 @default.
• W2020833122 cites W1998043521 @default.
• W2020833122 cites W2000485285 @default.
• W2020833122 cites W2001728969 @default.
• W2020833122 cites W2005020005 @default.
• W2020833122 cites W2009429694 @default.
• W2020833122 cites W2011665876 @default.
• W2020833122 cites W2012767314 @default.
• W2020833122 cites W2014004239 @default.
• W2020833122 cites W2014007136 @default.
• W2020833122 cites W2017227716 @default.
• W2020833122 cites W2019191832 @default.
• W2020833122 cites W2019201578 @default.
• W2020833122 cites W2020077263 @default.
• W2020833122 cites W2029414473 @default.
• W2020833122 cites W2029432539 @default.
• W2020833122 cites W2031094958 @default.
• W2020833122 cites W2041635772 @default.
• W2020833122 cites W2044444207 @default.
• W2020833122 cites W2045714155 @default.
• W2020833122 cites W2048005807 @default.
• W2020833122 cites W2049899770 @default.
• W2020833122 cites W2051071188 @default.
• W2020833122 cites W2051812342 @default.
• W2020833122 cites W2065312046 @default.
• W2020833122 cites W2068632889 @default.
• W2020833122 cites W2070510853 @default.
• W2020833122 cites W2071258820 @default.
• W2020833122 cites W2071791804 @default.
• W2020833122 cites W2073692210 @default.
• W2020833122 cites W2073744130 @default.
• W2020833122 cites W2077725247 @default.
• W2020833122 cites W2078879688 @default.
• W2020833122 cites W2080944497 @default.
• W2020833122 cites W2084268808 @default.
• W2020833122 cites W2084906226 @default.
• W2020833122 cites W2084983915 @default.
• W2020833122 cites W2087222666 @default.
• W2020833122 cites W2087454739 @default.
• W2020833122 cites W2089229689 @default.
• W2020833122 cites W2090698166 @default.
• W2020833122 cites W2092340811 @default.
• W2020833122 cites W2094846661 @default.
• W2020833122 cites W2096610541 @default.
• W2020833122 cites W2100726270 @default.
• W2020833122 cites W2103735966 @default.
• W2020833122 cites W2115583232 @default.
• W2020833122 cites W2127483997 @default.
• W2020833122 cites W2132581079 @default.
• W2020833122 cites W2135947516 @default.
• W2020833122 cites W2144486308 @default.
• W2020833122 cites W2148467233 @default.
• W2020833122 cites W2148622949 @default.
• W2020833122 cites W2153098831 @default.
• W2020833122 cites W2156140567 @default.
• W2020833122 cites W2162400220 @default.
• W2020833122 doi "https://doi.org/10.1016/j.pain.2010.10.015" @default.
• W2020833122 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21071147" @default.
• W2020833122 hasPublicationYear "2011" @default.
• W2020833122 type Work @default.
• W2020833122 sameAs 2020833122 @default.
• W2020833122 citedByCount "88" @default.
• W2020833122 countsByYear W20208331222012 @default.
• W2020833122 countsByYear W20208331222013 @default.
• W2020833122 countsByYear W20208331222014 @default.
• W2020833122 countsByYear W20208331222015 @default.
• W2020833122 countsByYear W20208331222016 @default.
• W2020833122 countsByYear W20208331222017 @default.
• W2020833122 countsByYear W20208331222018 @default.
• W2020833122 countsByYear W20208331222019 @default.
• W2020833122 countsByYear W20208331222020 @default.
• W2020833122 countsByYear W20208331222021 @default.
• W2020833122 countsByYear W20208331222022 @default.
• W2020833122 crossrefType "journal-article" @default.

• next