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- W2020844736 abstract "Following intrastriatal microinjection of haloperidol, the binding sites were demonstrated using ultraimmunohistochemistry. Haloperidol immunoreactive neurons began to appear 1 hr after the injection and dispersed far from the injection site as time passed. Electron microscopically, haloperidol binding sites were visualized as a soluble form. The immunoreaction products were seen throughout the cytoplasm but avoided the nuclear membrane, cisternal structures and most of the mitochondria. The haloperidol immunoreaction products showed shading differences in each cytoplasm, which was understood to be due to various states of affinity to the ligand. Based on these findings, a new concept of receptors is proposed: There are spare receptors before functioning and active receptors having a higher affinity for theligand.Four out of six neuronal types in the rat neostriatum, according to the classification by Kaiya et al. (13, 15), showed haloperidol immunoreaction products." @default.
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- W2020844736 date "1983-01-01" @default.
- W2020844736 modified "2023-09-23" @default.
- W2020844736 title "Fine structure of haloperidol binding sites in the neostriatum: An ultraimmunohistochemical attempt to visualize haloperidol/dopamine receptors." @default.
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- W2020844736 doi "https://doi.org/10.1267/ahc.16.119" @default.
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