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- W2020845461 abstract "Previous investigations have shown ear lymph to increase in volume and red cell concentration in many rabbits with severe thrombocytopenia. These animals had been exposed to whole body irradiation with the ears shielded. 125I-albumin was given intravenously on one or several occasions to 7 normal and 18 such irradiated rabbits, whereafter the rate of disappearance of the albumin from plasma during the next 1.5 hr was measured. This disappearance rate was found to be increased in those rabbits which showed thrombocytopenia and increased red cell concentration in their lymph. In seven irradiated animals, five with and two without signs of capillary leakage, an ear was cut off 3 hr after an iv injection of 125I-albumin. The amount of labeled albumin in the extravascular space was definitely increased in all five animals with leakage but was normal in the two others. Two of the five former animals also showed a high total tissue water content. Five thrombocytopenic rabbits with capillary leakage were given a transfusion with washed platelets. This changed the albumin disappearance rate in a normal direction in all five rabbits. It is concluded that in vivo capillary permeability to protein is often increased in animals suffering from postirradiation thrombocytopenia. When this occurs, increased permeation of red cells from blood to lymph is also seen." @default.
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- W2020845461 title "Increased permeability of capillaries to protein during thrombocytopenia an experimental study in the rabbit" @default.
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- W2020845461 doi "https://doi.org/10.1016/0026-2862(74)90016-8" @default.
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